Renslo AR - Search Results

1

Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.

Torelli NJ, Akhtar A, DeFrees K, Jaishankar P, Pemberton OA, Zhang X, Johnson C, Renslo AR, Chen Y. Torelli NJ, et al. Among authors: renslo ar. ACS Infect Dis. 2019 Jun 14;5(6):1013-1021. doi: 10.1021/acsinfecdis.9b00052. Epub 2019 Apr 15. ACS Infect Dis. 2019. PMID: 30942078

2

Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate.

Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gordeev MF. Renslo AR, et al. Org Lett. 2005 Jun 23;7(13):2627-30. doi: 10.1021/ol050730h. Org Lett. 2005. PMID: 15957907

3

Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones.

Renslo AR, Jaishankar P, Venkatachalam R, Hackbarth C, Lopez S, Patel DV, Gordeev MF. Renslo AR, et al. J Med Chem. 2005 Jul 28;48(15):5009-24. doi: 10.1021/jm058204j. J Med Chem. 2005. PMID: 16033280

4

A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials.

Renslo AR, Atuegbu A, Herradura P, Jaishankar P, Ji M, Leach KL, Huband MD, Dermyer MR, Wu L, Vara Prasad JV, Gordeev MF. Renslo AR, et al. Bioorg Med Chem Lett. 2007 Sep 15;17(18):5036-40. doi: 10.1016/j.bmcl.2007.07.022. Epub 2007 Jul 13. Bioorg Med Chem Lett. 2007. PMID: 17681758

5

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.

Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. Jaishankar P, et al. Among authors: renslo ar. Bioorg Med Chem Lett. 2008 Jan 15;18(2):624-8. doi: 10.1016/j.bmcl.2007.11.070. Epub 2007 Nov 22. Bioorg Med Chem Lett. 2008. PMID: 18055204

6

Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.

Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Bryant C, et al. Among authors: renslo ar. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6218-21. doi: 10.1016/j.bmcl.2009.08.098. Epub 2009 Sep 3. Bioorg Med Chem Lett. 2009. PMID: 19773167 Free PMC article.

7

Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase.

Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y. Nichols DA, et al. Among authors: renslo ar. J Med Chem. 2012 Mar 8;55(5):2163-72. doi: 10.1021/jm2014138. Epub 2012 Feb 14. J Med Chem. 2012. PMID: 22296601

8

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Heise CE, et al. Among authors: renslo ar. PLoS One. 2012;7(12):e50864. doi: 10.1371/journal.pone.0050864. Epub 2012 Dec 5. PLoS One. 2012. PMID: 23227217 Free PMC article.

9

Modulating caspase activity: beyond the active site.

Murray J, Renslo AR. Murray J, et al. Among authors: renslo ar. Curr Opin Struct Biol. 2013 Dec;23(6):812-9. doi: 10.1016/j.sbi.2013.10.002. Epub 2013 Nov 8. Curr Opin Struct Biol. 2013. PMID: 24215810 Review.

10

Tailoring small molecules for an allosteric site on procaspase-6.

Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Murray J, et al. Among authors: renslo ar. ChemMedChem. 2014 Jan;9(1):73-7, 2. doi: 10.1002/cmdc.201300424. Epub 2013 Nov 20. ChemMedChem. 2014. PMID: 24259468

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