Haak AJ - Search Results

1

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma.

Kahl DJ, Hutchings KM, Lisabeth EM, Haak AJ, Leipprandt JR, Dexheimer T, Khanna D, Tsou PS, Campbell PL, Fox DA, Wen B, Sun D, Bailie M, Neubig RR, Larsen SD. Kahl DJ, et al. Among authors: haak aj. J Med Chem. 2019 May 9;62(9):4350-4369. doi: 10.1021/acs.jmedchem.8b01772. Epub 2019 Apr 18. J Med Chem. 2019. PMID: 30951312 Free PMC article.

2

Survey of Dopamine Receptor D2 Antagonists as Retinal Antifibrotics.

Gao AY, Whaley MG, Saraf N, Bakri SJ, Haak AJ. Gao AY, et al. Among authors: haak aj. J Ocul Pharmacol Ther. 2024 Oct;40(8):536-542. doi: 10.1089/jop.2024.0006. Epub 2024 Aug 29. J Ocul Pharmacol Ther. 2024. PMID: 39206555

3

Non-canonical IKB kinases regulate YAP/TAZ and pathological vascular remodeling behaviors in pulmonary artery smooth muscle cells.

Aravamudhan A, Dieffenbach PB, Choi KM, Link PA, Meridew JA, Haak AJ, Fredenburgh LE, Tschumperlin DJ. Aravamudhan A, et al. Among authors: haak aj. Physiol Rep. 2024 Apr;12(7):e15999. doi: 10.14814/phy2.15999. Physiol Rep. 2024. PMID: 38610069 Free PMC article.

4

In vitro laboratory models of proliferative vitreoretinopathy.

Gao AY, Haak AJ, Bakri SJ. Gao AY, et al. Among authors: haak aj. Surv Ophthalmol. 2023 Sep-Oct;68(5):861-874. doi: 10.1016/j.survophthal.2023.05.007. Epub 2023 May 19. Surv Ophthalmol. 2023. PMID: 37209723 Review.

5

Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.

Bell JL, Haak AJ, Wade SM, Kirchhoff PD, Neubig RR, Larsen SD. Bell JL, et al. Among authors: haak aj. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32. doi: 10.1016/j.bmcl.2013.04.080. Epub 2013 May 7. Bioorg Med Chem Lett. 2013. PMID: 23707258 Free PMC article.

6

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.

Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD. Bell JL, et al. Among authors: haak aj. Beilstein J Org Chem. 2013 May 21;9:966-73. doi: 10.3762/bjoc.9.111. Print 2013. Beilstein J Org Chem. 2013. PMID: 23766813 Free PMC article.

7

Novel Rho/MRTF/SRF inhibitors block matrix-stiffness and TGF-β-induced fibrogenesis in human colonic myofibroblasts.

Johnson LA, Rodansky ES, Haak AJ, Larsen SD, Neubig RR, Higgins PD. Johnson LA, et al. Among authors: haak aj. Inflamm Bowel Dis. 2014 Jan;20(1):154-65. doi: 10.1097/01.MIB.0000437615.98881.31. Inflamm Bowel Dis. 2014. PMID: 24280883 Free PMC article.

8

The role of HTS in drug discovery at the University of Michigan.

Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH. Larsen MJ, et al. Comb Chem High Throughput Screen. 2014 Mar;17(3):210-30. doi: 10.2174/1386207317666140109121546. Comb Chem High Throughput Screen. 2014. PMID: 24409957 Free PMC article. Review.

9

Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury.

Haak AJ, Tsou PS, Amin MA, Ruth JH, Campbell P, Fox DA, Khanna D, Larsen SD, Neubig RR. Haak AJ, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4. J Pharmacol Exp Ther. 2014. PMID: 24706986 Free PMC article.

10

Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.

Tsou PS, Haak AJ, Khanna D, Neubig RR. Tsou PS, et al. Among authors: haak aj. Am J Physiol Cell Physiol. 2014 Jul 1;307(1):C2-13. doi: 10.1152/ajpcell.00060.2014. Epub 2014 Apr 16. Am J Physiol Cell Physiol. 2014. PMID: 24740541 Free PMC article. Review.

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