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Targeted antibody and cytokine cancer immunotherapies through collagen affinity.
Ishihara J, Ishihara A, Sasaki K, Lee SS, Williford JM, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA. Ishihara J, et al. Among authors: ishihara a. Sci Transl Med. 2019 Apr 10;11(487):eaau3259. doi: 10.1126/scitranslmed.aau3259. Sci Transl Med. 2019. PMID: 30971453 Free PMC article.
The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing.
Ishihara J, Ishihara A, Starke RD, Peghaire CR, Smith KE, McKinnon TAJ, Tabata Y, Sasaki K, White MJV, Fukunaga K, Laffan MA, Lutolf MP, Randi AM, Hubbell JA. Ishihara J, et al. Among authors: ishihara a. Blood. 2019 Jun 13;133(24):2559-2569. doi: 10.1182/blood.2019000510. Epub 2019 Apr 11. Blood. 2019. PMID: 30975637 Free PMC article.
Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours.
Mansurov A, Ishihara J, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford JM, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA. Mansurov A, et al. Among authors: ishihara j, ishihara a. Nat Biomed Eng. 2020 May;4(5):531-543. doi: 10.1038/s41551-020-0549-2. Epub 2020 Apr 13. Nat Biomed Eng. 2020. PMID: 32284554 Free PMC article.
Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis.
Ishihara A, Ishihara J, Watkins EA, Tremain AC, Nguyen M, Solanki A, Katsumata K, Mansurov A, Budina E, Alpar AT, Hosseinchi P, Maillat L, Reda JW, Kageyama T, Swartz MA, Yuba E, Hubbell JA. Ishihara A, et al. Among authors: ishihara j. Nat Biomed Eng. 2021 May;5(5):387-398. doi: 10.1038/s41551-020-00627-3. Epub 2020 Oct 12. Nat Biomed Eng. 2021. PMID: 33046864
852 results