Geraghty NJ - Search Results

1

Altered donor P2X7 activity in human leukocytes correlates with P2RX7 genotype but does not affect the development of graft-versus-host disease in humanised mice.

Adhikary SR, Geraghty NJ, Cuthbertson P, Sluyter R, Watson D. Adhikary SR, et al. Among authors: geraghty nj. Purinergic Signal. 2019 Jun;15(2):177-192. doi: 10.1007/s11302-019-09651-8. Epub 2019 Apr 18. Purinergic Signal. 2019. PMID: 31001750 Free PMC article.

2

Activation of the P2X7 receptor induces the rapid shedding of CD23 from human and murine B cells.

Pupovac A, Geraghty NJ, Watson D, Sluyter R. Pupovac A, et al. Among authors: geraghty nj. Immunol Cell Biol. 2015 Jan;93(1):77-85. doi: 10.1038/icb.2014.69. Epub 2014 Aug 26. Immunol Cell Biol. 2015. PMID: 25155463

3

The P2X7 receptor is not essential for development of imiquimod-induced psoriasis-like inflammation in mice.

Geraghty NJ, Mansfield KJ, Fuller SJ, Watson D, Sluyter R. Geraghty NJ, et al. Purinergic Signal. 2017 Dec;13(4):405-415. doi: 10.1007/s11302-017-9569-0. Epub 2017 Jun 8. Purinergic Signal. 2017. PMID: 28597172 Free PMC article.

4

The P2X7 receptor antagonist Brilliant Blue G reduces serum human interferon-γ in a humanized mouse model of graft-versus-host disease.

Geraghty NJ, Belfiore L, Ly D, Adhikary SR, Fuller SJ, Varikatt W, Sanderson-Smith ML, Sluyter V, Alexander SI, Sluyter R, Watson D. Geraghty NJ, et al. Clin Exp Immunol. 2017 Oct;190(1):79-95. doi: 10.1111/cei.13005. Epub 2017 Jul 24. Clin Exp Immunol. 2017. PMID: 28665482 Free PMC article.

5

Long-term treatment with the P2X7 receptor antagonist Brilliant Blue G reduces liver inflammation in a humanized mouse model of graft-versus-host disease.

Geraghty NJ, Watson D, Sluyter R. Geraghty NJ, et al. Cell Immunol. 2019 Feb;336:12-19. doi: 10.1016/j.cellimm.2018.12.001. Epub 2018 Dec 4. Cell Immunol. 2019. PMID: 30545568

6

Increased splenic human CD4⁺:CD8⁺ T cell ratios, serum human interferon-γ and intestinal human interleukin-17 are associated with clinical graft-versus-host disease in humanized mice.

Geraghty NJ, Belfiore L, Adhikary SR, Alexander SI, Sluyter R, Watson D. Geraghty NJ, et al. Transpl Immunol. 2019 Jun;54:38-46. doi: 10.1016/j.trim.2019.02.003. Epub 2019 Feb 8. Transpl Immunol. 2019. PMID: 30743002

7

Pharmacological blockade of the CD39/CD73 pathway but not adenosine receptors augments disease in a humanized mouse model of graft-versus-host disease.

Geraghty NJ, Watson D, Sluyter R. Geraghty NJ, et al. Immunol Cell Biol. 2019 Jul;97(6):597-610. doi: 10.1111/imcb.12251. Epub 2019 Apr 29. Immunol Cell Biol. 2019. PMID: 30957314

8

The A_2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease.

Geraghty NJ, Adhikary SR, Watson D, Sluyter R. Geraghty NJ, et al. Int Immunopharmacol. 2019 Jul;72:479-486. doi: 10.1016/j.intimp.2019.04.037. Epub 2019 Apr 30. Int Immunopharmacol. 2019. PMID: 31051404

9

Increased P2X7 expression in the gastrointestinal tract and skin in a humanised mouse model of graft-versus-host disease.

Cuthbertson P, Adhikary SR, Geraghty NJ, Guy TV, Hadjiashrafi A, Fuller SJ, Ly D, Watson D, Sluyter R. Cuthbertson P, et al. Among authors: geraghty nj. Clin Sci (Lond). 2020 Jan 31;134(2):207-223. doi: 10.1042/CS20191086. Clin Sci (Lond). 2020. PMID: 31934722

10

The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1^G93A mice.

Ly D, Dongol A, Cuthbertson P, Guy TV, Geraghty NJ, Sophocleous RA, Sin L, Turner BJ, Watson D, Yerbury JJ, Sluyter R. Ly D, et al. Among authors: geraghty nj. Purinergic Signal. 2020 Mar;16(1):109-122. doi: 10.1007/s11302-020-09692-4. Epub 2020 Mar 13. Purinergic Signal. 2020. PMID: 32170537 Free PMC article.

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