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Page 1
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW. Harris PA, et al. Among authors: faucher n. J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2. J Med Chem. 2019. PMID: 31013427
The discovery of equipotent PPARalpha/gamma dual activators.
Martres P, Faucher N, Laroze A, Pineau O, Fouchet MH, Potvain F, Grillot D, Beneton V. Martres P, et al. Among authors: faucher n. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6251-4. doi: 10.1016/j.bmcl.2008.09.094. Epub 2008 Oct 1. Bioorg Med Chem Lett. 2008. PMID: 18947994
Pharmacological properties of acid N-thiazolylamide FFA2 agonists.
Brown AJ, Tsoulou C, Ward E, Gower E, Bhudia N, Chowdhury F, Dean TW, Faucher N, Gangar A, Dowell SJ. Brown AJ, et al. Among authors: faucher n. Pharmacol Res Perspect. 2015 Jun;3(3):e00141. doi: 10.1002/prp2.141. Epub 2015 May 8. Pharmacol Res Perspect. 2015. PMID: 26236484 Free PMC article.
Highly chemoselective hydrogenolysis of iodoarenes.
Faucher N, Ambroise Y, Cintrat JC, Doris E, Pillon F, Rousseau B. Faucher N, et al. J Org Chem. 2002 Feb 8;67(3):932-4. doi: 10.1021/jo0109669. J Org Chem. 2002. PMID: 11856040
The shortest route to chiral ditosylmethylamine.
Faucher N, Cintrat JC, Berthault P, Rousseau B. Faucher N, et al. Angew Chem Int Ed Engl. 2002 Feb 1;41(3):497-8. doi: 10.1002/1521-3773(20020201)41:3<497::aid-anie497>3.0.co;2-g. Angew Chem Int Ed Engl. 2002. PMID: 12491391 No abstract available.
53 results