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The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly CE, Douglas O, Kamalian L, Jenkins RE, Beckett AJ, Penman SL, Williams DP, Monshouwer M, Simic D, Snoeys J, Park BK, Chadwick AE. Jolly CE, et al. Among authors: park bk. Toxicol Appl Pharmacol. 2020 Sep 15;403:115163. doi: 10.1016/j.taap.2020.115163. Epub 2020 Jul 28. Toxicol Appl Pharmacol. 2020. PMID: 32730777 Free PMC article.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Weaver RJ, Blomme EA, Chadwick AE, Copple IM, Gerets HHJ, Goldring CE, Guillouzo A, Hewitt PG, Ingelman-Sundberg M, Jensen KG, Juhila S, Klingmüller U, Labbe G, Liguori MJ, Lovatt CA, Morgan P, Naisbitt DJ, Pieters RHH, Snoeys J, van de Water B, Williams DP, Park BK. Weaver RJ, et al. Among authors: park bk. Nat Rev Drug Discov. 2020 Feb;19(2):131-148. doi: 10.1038/s41573-019-0048-x. Epub 2019 Nov 20. Nat Rev Drug Discov. 2020. PMID: 31748707 Free article. Review.
The role of metabolic activation in drug-induced hepatotoxicity.
Park BK, Kitteringham NR, Maggs JL, Pirmohamed M, Williams DP. Park BK, et al. Annu Rev Pharmacol Toxicol. 2005;45:177-202. doi: 10.1146/annurev.pharmtox.45.120403.100058. Annu Rev Pharmacol Toxicol. 2005. PMID: 15822174 Review.
Diet restriction inhibits apoptosis and HMGB1 oxidation and promotes inflammatory cell recruitment during acetaminophen hepatotoxicity.
Antoine DJ, Williams DP, Kipar A, Laverty H, Park BK. Antoine DJ, et al. Among authors: park bk. Mol Med. 2010 Nov-Dec;16(11-12):479-90. doi: 10.2119/molmed.2010.00126. Epub 2010 Aug 27. Mol Med. 2010. Retraction in: Mol Med. 2020 Dec 30;26(1):130. doi: 10.1186/s10020-020-00262-3 PMID: 20811657 Free PMC article. Retracted.
1,552 results