Kleinjans JC - Search Results

1

Human 3D multicellular microtissues: An upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity.

Jiang J, Messner S, Kelm JM, van Herwijnen M, Jennen DGJ, Kleinjans JC, de Kok TM. Jiang J, et al. Among authors: kleinjans jc. Toxicol Lett. 2019 Sep 15;312:34-44. doi: 10.1016/j.toxlet.2019.05.004. Epub 2019 May 3. Toxicol Lett. 2019. PMID: 31059760 Free article.

2

Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells.

Hebels DG, Brauers KJ, van Herwijnen MH, Georgiadis PA, Kyrtopoulos SA, Kleinjans JC, de Kok TM. Hebels DG, et al. Among authors: kleinjans jc. Toxicol Lett. 2011 Dec 15;207(3):232-41. doi: 10.1016/j.toxlet.2011.09.012. Epub 2011 Sep 19. Toxicol Lett. 2011. PMID: 21946166

3

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Jiang J, Briedé JJ, Jennen DG, Van Summeren A, Saritas-Brauers K, Schaart G, Kleinjans JC, de Kok TM. Jiang J, et al. Among authors: kleinjans jc. Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19. Toxicol Lett. 2015. PMID: 25704631

4

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Jiang J, Briedé JJ, Jennen DG, Kleinjans JC, de Kok TM. Jiang J, et al. Among authors: kleinjans jc. Toxicol Lett. 2015 Jun 15;235(3):218-9. doi: 10.1016/j.toxlet.2015.04.003. Epub 2015 Apr 17. Toxicol Lett. 2015. PMID: 25895633 No abstract available.

5

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma.

Rieswijk L, Claessen SM, Bekers O, van Herwijnen M, Theunissen DH, Jennen DG, de Kok TM, Kleinjans JC, van Breda SG. Rieswijk L, et al. Among authors: kleinjans jc. Toxicology. 2016 Mar 28;350-352:31-9. doi: 10.1016/j.tox.2016.05.002. Epub 2016 May 3. Toxicology. 2016. PMID: 27153756

6

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Wolters JE, van Herwijnen MH, Theunissen DH, Jennen DG, Van den Hof WF, de Kok TM, Schaap FG, van Breda SG, Kleinjans JC. Wolters JE, et al. Among authors: kleinjans jc. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174. doi: 10.1021/acs.chemrestox.6b00337. Epub 2016 Dec 2. Chem Res Toxicol. 2016. PMID: 27989131

7

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.

van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS. van Breda SGJ, et al. Toxicology. 2018 Jan 15;393:160-170. doi: 10.1016/j.tox.2017.11.013. Epub 2017 Nov 14. Toxicology. 2018. PMID: 29154799 Free article.

8

Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids.

Rodrigues D, van Kampen R, van Bodegraven AA, Kleinjans JCS, Jennen DGJ, de Kok TM. Rodrigues D, et al. Among authors: kleinjans jcs. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29. Toxicol Lett. 2022. PMID: 36183961 Free article.

9

Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach.

Deferme L, Briedé JJ, Claessen SM, Jennen DG, Cavill R, Kleinjans JC. Deferme L, et al. Among authors: kleinjans jc. Toxicology. 2013 Apr 5;306:24-34. doi: 10.1016/j.tox.2013.02.001. Epub 2013 Feb 11. Toxicology. 2013. PMID: 23410634

10

Omics-based identification of the combined effects of idiosyncratic drugs and inflammatory cytokines on the development of drug-induced liver injury.

Jiang J, Mathijs K, Timmermans L, Claessen SM, Hecka A, Weusten J, Peters R, van Delft JH, Kleinjans JCS, Jennen DGJ, de Kok TM. Jiang J, et al. Toxicol Appl Pharmacol. 2017 Oct 1;332:100-108. doi: 10.1016/j.taap.2017.07.014. Epub 2017 Jul 18. Toxicol Appl Pharmacol. 2017. PMID: 28733206

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