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Neuropeptide 26RFa (QRFP) is a key regulator of glucose homeostasis and its activity is markedly altered in obese/hyperglycemic mice.
Prévost G, Arabo A, Le Solliec MA, Bons J, Picot M, Maucotel J, Berrahmoune H, El Mehdi M, Cherifi S, Benani A, Nédélec E, Coëffier M, Leprince J, Nordqvist A, Brunel V, Déchelotte P, Lefebvre H, Anouar Y, Chartrel N. Prévost G, et al. Among authors: chartrel n. Am J Physiol Endocrinol Metab. 2019 Jul 1;317(1):E147-E157. doi: 10.1152/ajpendo.00540.2018. Epub 2019 May 14. Am J Physiol Endocrinol Metab. 2019. PMID: 31084498 Free article.
Hypothalamic Neuropeptide 26RFa Acts as an Incretin to Regulate Glucose Homeostasis.
Prévost G, Jeandel L, Arabo A, Coëffier M, El Ouahli M, Picot M, Alexandre D, Gobet F, Leprince J, Berrahmoune H, Déchelotte P, Malagon M, Bonner C, Kerr-Conte J, Chigr F, Lefebvre H, Anouar Y, Chartrel N. Prévost G, et al. Among authors: chartrel n. Diabetes. 2015 Aug;64(8):2805-16. doi: 10.2337/db14-1864. Epub 2015 Apr 9. Diabetes. 2015. PMID: 25858563
The 26RFa (QRFP)/GPR103 neuropeptidergic system in mice relays insulin signalling into the brain to regulate glucose homeostasis.
El Mehdi M, Takhlidjt S, Devère M, Arabo A, Le Solliec MA, Maucotel J, Bénani A, Nedelec E, Duparc C, Lefranc B, Leprince J, Anouar Y, Prévost G, Chartrel N, Picot M. El Mehdi M, et al. Among authors: chartrel n. Diabetologia. 2022 Jul;65(7):1198-1211. doi: 10.1007/s00125-022-05706-5. Epub 2022 Apr 27. Diabetologia. 2022. PMID: 35476025
Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP).
El-Mehdi M, Takhlidjt S, Khiar F, Prévost G, do Rego JL, do Rego JC, Benani A, Nedelec E, Godefroy D, Arabo A, Lefranc B, Leprince J, Anouar Y, Chartrel N, Picot M. El-Mehdi M, et al. Among authors: chartrel n. BMJ Open Diabetes Res Care. 2020 Feb;8(1):e000942. doi: 10.1136/bmjdrc-2019-000942. BMJ Open Diabetes Res Care. 2020. PMID: 32114486 Free PMC article.
113 results