Wang G - Search Results

1

The past, present and future of potential small-molecule drugs targeting p53-MDM2/MDMX for cancer therapy.

Liu Y, Wang X, Wang G, Yang Y, Yuan Y, Ouyang L. Liu Y, et al. Among authors: wang x, wang g. Eur J Med Chem. 2019 Aug 15;176:92-104. doi: 10.1016/j.ejmech.2019.05.018. Epub 2019 May 8. Eur J Med Chem. 2019. PMID: 31100649 Review.

2

Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer.

Ouyang L, Zhang L, Liu J, Fu L, Yao D, Zhao Y, Zhang S, Wang G, He G, Liu B. Ouyang L, et al. Among authors: wang g. J Med Chem. 2017 Dec 28;60(24):9990-10012. doi: 10.1021/acs.jmedchem.7b00275. Epub 2017 Dec 7. J Med Chem. 2017. PMID: 29172540

3

Design, synthesis and structure-activity relationship of a focused library of β-phenylalanine derivatives as novel eEF2K inhibitors with apoptosis-inducing mechanisms in breast cancer.

Guo Y, Zhao Y, Wang G, Chen Y, Jiang Y, Ouyang L, Liu B. Guo Y, et al. Among authors: wang g. Eur J Med Chem. 2018 Jan 1;143:402-418. doi: 10.1016/j.ejmech.2017.11.065. Epub 2017 Dec 1. Eur J Med Chem. 2018. PMID: 29202403

4

Mechanisms of autophagy and relevant small-molecule compounds for targeted cancer therapy.

Zhang J, Wang G, Zhou Y, Chen Y, Ouyang L, Liu B. Zhang J, et al. Among authors: wang g. Cell Mol Life Sci. 2018 May;75(10):1803-1826. doi: 10.1007/s00018-018-2759-2. Epub 2018 Feb 7. Cell Mol Life Sci. 2018. PMID: 29417176 Free PMC article. Review.

5

Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson's Disease Treatment.

Ouyang L, Zhang L, Zhang S, Yao D, Zhao Y, Wang G, Fu L, Lei P, Liu B. Ouyang L, et al. Among authors: wang g. J Med Chem. 2018 Apr 12;61(7):2776-2792. doi: 10.1021/acs.jmedchem.7b01575. Epub 2018 Mar 29. J Med Chem. 2018. PMID: 29561612

6

Deciphering the Rules of in Silico Autophagy Methods for Expediting Medicinal Research.

Chen Y, Wang G, Cai H, Sun Y, Ouyang L, Liu B. Chen Y, et al. Among authors: wang g. J Med Chem. 2019 Aug 8;62(15):6831-6842. doi: 10.1021/acs.jmedchem.8b01673. Epub 2019 Mar 28. J Med Chem. 2019. PMID: 30888814 Review.

7

Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms.

Li Y, Wang G, Liu J, Ouyang L. Li Y, et al. Among authors: wang g. Eur J Med Chem. 2020 Feb 15;188:111972. doi: 10.1016/j.ejmech.2019.111972. Epub 2019 Dec 23. Eur J Med Chem. 2020. PMID: 31884408 Review.

8

Discovery of a Novel Dual-Target Inhibitor of ERK1 and ERK5 That Induces Regulated Cell Death to Overcome Compensatory Mechanism in Specific Tumor Types.

Wang G, Zhao Y, Liu Y, Sun D, Zhen Y, Liu J, Fu L, Zhang L, Ouyang L. Wang G, et al. J Med Chem. 2020 Apr 23;63(8):3976-3995. doi: 10.1021/acs.jmedchem.9b01896. Epub 2020 Mar 5. J Med Chem. 2020. PMID: 32078308

9

Brain-Derived Neurotrophic Factor and Its Potential Therapeutic Role in Stroke Comorbidities.

Liu W, Wang X, O'Connor M, Wang G, Han F. Liu W, et al. Among authors: wang x, wang g. Neural Plast. 2020 Jan 27;2020:1969482. doi: 10.1155/2020/1969482. eCollection 2020. Neural Plast. 2020. PMID: 32399020 Free PMC article. Review.

10

Designing an eEF2K-Targeting PROTAC small molecule that induces apoptosis in MDA-MB-231 cells.

Liu Y, Zhen Y, Wang G, Yang G, Fu L, Liu B, Ouyang L. Liu Y, et al. Among authors: wang g. Eur J Med Chem. 2020 Oct 15;204:112505. doi: 10.1016/j.ejmech.2020.112505. Epub 2020 Jul 18. Eur J Med Chem. 2020. PMID: 32717479

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