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Page 1
HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.
Collier MP, Alderson TR, de Villiers CP, Nicholls D, Gastall HY, Allison TM, Degiacomi MT, Jiang H, Mlynek G, Fürst DO, van der Ven PFM, Djinovic-Carugo K, Baldwin AJ, Watkins H, Gehmlich K, Benesch JLP. Collier MP, et al. Among authors: gastall hy. Sci Adv. 2019 May 22;5(5):eaav8421. doi: 10.1126/sciadv.aav8421. eCollection 2019 May. Sci Adv. 2019. PMID: 31131323 Free PMC article.
Local unfolding of the HSP27 monomer regulates chaperone activity.
Alderson TR, Roche J, Gastall HY, Dias DM, Pritišanac I, Ying J, Bax A, Benesch JLP, Baldwin AJ. Alderson TR, et al. Among authors: gastall hy. Nat Commun. 2019 Mar 6;10(1):1068. doi: 10.1038/s41467-019-08557-8. Nat Commun. 2019. PMID: 30842409 Free PMC article.
A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteins.
Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, Lp Benesch J. Alderson TR, et al. Among authors: gastall hy. EMBO J. 2021 Apr 15;40(8):e103811. doi: 10.15252/embj.2019103811. Epub 2021 Mar 1. EMBO J. 2021. PMID: 33644875 Free PMC article.