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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB); Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kaw… See abstract for full author list ➔ van der Lee SJ, et al. Among authors: zettergren a. Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27. Acta Neuropathol. 2019. PMID: 31131421 Free PMC article.
A longitudinal resource for population neuroscience of school-age children and adolescents in China.
Fan XR, Wang YS, Chang D, Yang N, Rong MJ, Zhang Z, He Y, Hou X, Zhou Q, Gong ZQ, Cao LZ, Dong HM, Nie JJ, Chen LZ, Zhang Q, Zhang JX, Zhang L, Li HJ, Bao M, Chen A, Chen J, Chen X, Ding J, Dong X, Du Y, Feng C, Feng T, Fu X, Ge LK, Hong B, Hu X, Huang W, Jiang C, Li L, Li Q, Li S, Liu X, Mo F, Qiu J, Su XQ, Wei GX, Wu Y, Xia H, Yan CG, Yan ZX, Yang X, Zhang W, Zhao K, Zhu L; Chinese Color Nest Consortium (CCNC); Lifespan Brain Chart Consortium (LBCC); Zuo XN. Fan XR, et al. Sci Data. 2023 Aug 21;10(1):545. doi: 10.1038/s41597-023-02377-8. Sci Data. 2023. PMID: 37604823 Free PMC article.
117 results