Portoghese PS - Search Results

1

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Zhang X, et al. Among authors: portoghese ps. FASEB J. 2019 Aug;33(8):9577-9587. doi: 10.1096/fj.201900173RRR. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31162938 Free PMC article.

2

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ opioid receptors.

Metcalf MD, Yekkirala AS, Powers MD, Kitto KF, Fairbanks CA, Wilcox GL, Portoghese PS. Metcalf MD, et al. Among authors: portoghese ps. ACS Chem Neurosci. 2012 Jul 18;3(7):505-9. doi: 10.1021/cn3000394. Epub 2012 May 22. ACS Chem Neurosci. 2012. PMID: 22860219 Free PMC article.

3

Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys.

Yekkirala AS, Banks ML, Lunzer MM, Negus SS, Rice KC, Portoghese PS. Yekkirala AS, et al. Among authors: portoghese ps. ACS Chem Neurosci. 2012 Sep 19;3(9):720-7. doi: 10.1021/cn300049m. Epub 2012 Jul 5. ACS Chem Neurosci. 2012. PMID: 23019498 Free PMC article.

4

Role of the spacer in conferring kappa opioid receptor selectivity to bivalent ligands related to norbinaltorphimine.

Portoghese PS, Garzon-Aburbeh A, Nagase H, Lin CE, Takemori AE. Portoghese PS, et al. J Med Chem. 1991 Apr;34(4):1292-6. doi: 10.1021/jm00108a008. J Med Chem. 1991. PMID: 1849995

5

Only one pharmacophore is required for the kappa opioid antagonist selectivity of norbinaltorphimine.

Portoghese PS, Nagase H, Takemori AE. Portoghese PS, et al. J Med Chem. 1988 Jul;31(7):1344-7. doi: 10.1021/jm00402a015. J Med Chem. 1988. PMID: 2838632

6

Structure-activity relationship of N17'-substituted norbinaltorphimine congeners. Role of the N17' basic group in the interaction with a putative address subsite on the kappa opioid receptor.

Portoghese PS, Lin CE, Farouz-Grant F, Takemori AE. Portoghese PS, et al. J Med Chem. 1994 May 13;37(10):1495-500. doi: 10.1021/jm00036a015. J Med Chem. 1994. PMID: 8182708

7

Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats.

Jutkiewicz EM, Walker NP, Folk JE, Rice KC, Portoghese PS, Woods JH, Traynor JR. Jutkiewicz EM, et al. Among authors: portoghese ps. J Pharmacol Exp Ther. 2005 Mar;312(3):1314-20. doi: 10.1124/jpet.104.078741. Epub 2004 Dec 1. J Pharmacol Exp Ther. 2005. PMID: 15574687 Free PMC article.

8

Synthesis and kappa-opioid antagonist selectivity of a norbinaltorphimine congener. Identification of the address moiety required for kappa-antagonist activity.

Lin CE, Takemori AE, Portoghese PS. Lin CE, et al. Among authors: portoghese ps. J Med Chem. 1993 Aug 6;36(16):2412-5. doi: 10.1021/jm00068a020. J Med Chem. 1993. PMID: 8360887

9

Selective naltrexone-derived opioid receptor antagonists.

Takemori AE, Portoghese PS. Takemori AE, et al. Among authors: portoghese ps. Annu Rev Pharmacol Toxicol. 1992;32:239-69. doi: 10.1146/annurev.pa.32.040192.001323. Annu Rev Pharmacol Toxicol. 1992. PMID: 1318671 Review.

10

Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists.

Larson DL, Jones RM, Hjorth SA, Schwartz TW, Portoghese PS. Larson DL, et al. Among authors: portoghese ps. J Med Chem. 2000 Apr 20;43(8):1573-6. doi: 10.1021/jm000059g. J Med Chem. 2000. PMID: 10780914

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

324 results

Search Page

Filters