Alag A - Search Results

1

E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.

Kadakia T, Tai X, Kruhlak M, Wisniewski J, Hwang IY, Roy S, Guinter TI, Alag A, Kehrl JH, Zhuang Y, Singer A. Kadakia T, et al. Among authors: alag a. J Exp Med. 2019 Aug 5;216(8):1749-1761. doi: 10.1084/jem.20182285. Epub 2019 Jun 14. J Exp Med. 2019. PMID: 31201207 Free PMC article.

2

Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.

Erman B, Alag AS, Dahle O, van Laethem F, Sarafova SD, Guinter TI, Sharrow SO, Grinberg A, Love PE, Singer A. Erman B, et al. Among authors: alag as. J Immunol. 2006 Nov 15;177(10):6613-25. doi: 10.4049/jimmunol.177.10.6613. J Immunol. 2006. PMID: 17082573

3

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A. Park JH, et al. Among authors: alag as. Nat Immunol. 2007 Oct;8(10):1049-59. doi: 10.1038/ni1512. Epub 2007 Sep 16. Nat Immunol. 2007. PMID: 17873878

4

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

Park JH, Adoro S, Guinter T, Erman B, Alag AS, Catalfamo M, Kimura MY, Cui Y, Lucas PJ, Gress RE, Kubo M, Hennighausen L, Feigenbaum L, Singer A. Park JH, et al. Among authors: alag as. Nat Immunol. 2010 Mar;11(3):257-64. doi: 10.1038/ni.1840. Epub 2010 Jan 31. Nat Immunol. 2010. PMID: 20118929 Free PMC article.

5

Coreceptor gene imprinting governs thymocyte lineage fate.

Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A. Adoro S, et al. Among authors: alag a. EMBO J. 2012 Jan 18;31(2):366-77. doi: 10.1038/emboj.2011.388. Epub 2011 Oct 28. EMBO J. 2012. PMID: 22036949 Free PMC article.

6

Conditional deletion of cytokine receptor chains reveals that IL-7 and IL-15 specify CD8 cytotoxic lineage fate in the thymus.

McCaughtry TM, Etzensperger R, Alag A, Tai X, Kurtulus S, Park JH, Grinberg A, Love P, Feigenbaum L, Erman B, Singer A. McCaughtry TM, et al. Among authors: alag a. J Exp Med. 2012 Nov 19;209(12):2263-76. doi: 10.1084/jem.20121505. Epub 2012 Oct 29. J Exp Med. 2012. PMID: 23109710 Free PMC article.

7

Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals.

Tai X, Erman B, Alag A, Mu J, Kimura M, Katz G, Guinter T, McCaughtry T, Etzensperger R, Feigenbaum L, Singer DS, Singer A. Tai X, et al. Among authors: alag a. Immunity. 2013 Jun 27;38(6):1116-28. doi: 10.1016/j.immuni.2013.02.022. Epub 2013 Jun 6. Immunity. 2013. PMID: 23746651 Free PMC article.

8

Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function.

Pobezinsky LA, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry TM, Kimura MY, Sharrow SO, Guinter TI, Feigenbaum L, Singer A. Pobezinsky LA, et al. Among authors: alag a. Nat Immunol. 2015 May;16(5):517-24. doi: 10.1038/ni.3146. Epub 2015 Apr 6. Nat Immunol. 2015. PMID: 25848867 Free PMC article.

9

Identification of lineage-specifying cytokines that signal all CD8⁺-cytotoxic-lineage-fate 'decisions' in the thymus.

Etzensperger R, Kadakia T, Tai X, Alag A, Guinter TI, Egawa T, Erman B, Singer A. Etzensperger R, et al. Among authors: alag a. Nat Immunol. 2017 Nov;18(11):1218-1227. doi: 10.1038/ni.3847. Epub 2017 Sep 25. Nat Immunol. 2017. PMID: 28945245 Free PMC article.

10

Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus.

Van Laethem F, Saba I, Lu J, Bhattacharya A, Tai X, Guinter TI, Engelhardt B, Alag A, Rojano M, Ashe JM, Hanada KI, Yang JC, Sun PD, Singer A. Van Laethem F, et al. Among authors: alag a. Front Immunol. 2020 Jun 16;11:1216. doi: 10.3389/fimmu.2020.01216. eCollection 2020. Front Immunol. 2020. PMID: 32612609 Free PMC article.

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