Extracellular α-synuclein enters dopaminergic cells by modulating flotillin-1-assisted dopamine transporter endocytosis.
Kobayashi J, Hasegawa T, Sugeno N, Yoshida S, Akiyama T, Fujimori K, Hatakeyama H, Miki Y, Tomiyama A, Kawata Y, Fukuda M, Kawahata I, Yamakuni T, Ezura M, Kikuchi A, Baba T, Takeda A, Kanzaki M, Wakabayashi K, Okano H, Aoki M.
Kobayashi J, et al. Among authors: takeda a.
FASEB J. 2019 Sep;33(9):10240-10256. doi: 10.1096/fj.201802051R. Epub 2019 Jun 18.
FASEB J. 2019.
PMID: 31211923
Moreover, we demonstrated that alpha-SYN itself exploited the DAT endocytic process to enter dopaminergic neuron-like cells, and both FLOT1 and DAT were found to be the components of LBs. Altogether, these findings revealed a novel role of extracellular alpha-SYN on cellul …
Moreover, we demonstrated that alpha-SYN itself exploited the DAT endocytic process to enter dopaminergic neuron-like cells, and both FLOT1 …