Adhikari AS - Search Results

1

β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.

Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM. Adhikari AS, et al. Nat Commun. 2019 Jun 18;10(1):2685. doi: 10.1038/s41467-019-10555-9. Nat Commun. 2019. PMID: 31213605 Free PMC article.

2

Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.

Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C, Adhikari AS, Taylor R, Liu C, Trivedi D, Ruppel KM. Spudich JA, et al. Among authors: adhikari as. J Exp Biol. 2016 Jan;219(Pt 2):161-7. doi: 10.1242/jeb.125930. J Exp Biol. 2016. PMID: 26792326 Free PMC article. Review.

3

Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.

Adhikari AS, Kooiker KB, Sarkar SS, Liu C, Bernstein D, Spudich JA, Ruppel KM. Adhikari AS, et al. Cell Rep. 2016 Dec 13;17(11):2857-2864. doi: 10.1016/j.celrep.2016.11.040. Cell Rep. 2016. PMID: 27974200 Free PMC article.

4

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.

Nag S, Trivedi DV, Sarkar SS, Adhikari AS, Sunitha MS, Sutton S, Ruppel KM, Spudich JA. Nag S, et al. Among authors: adhikari as. Nat Struct Mol Biol. 2017 Jun;24(6):525-533. doi: 10.1038/nsmb.3408. Epub 2017 May 8. Nat Struct Mol Biol. 2017. PMID: 28481356 Free PMC article.

5

Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.

Trivedi DV, Adhikari AS, Sarkar SS, Ruppel KM, Spudich JA. Trivedi DV, et al. Among authors: adhikari as. Biophys Rev. 2018 Feb;10(1):27-48. doi: 10.1007/s12551-017-0274-6. Epub 2017 Jul 17. Biophys Rev. 2018. PMID: 28717924 Free PMC article. Review.

6

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.

Sarkar SS, Trivedi DV, Morck MM, Adhikari AS, Pasha SN, Ruppel KM, Spudich JA. Sarkar SS, et al. Among authors: adhikari as. Sci Adv. 2020 Apr 3;6(14):eaax0069. doi: 10.1126/sciadv.aax0069. eCollection 2020 Apr. Sci Adv. 2020. PMID: 32284968 Free PMC article.

7

Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties.

Vera CD, Johnson CA, Walklate J, Adhikari A, Svicevic M, Mijailovich SM, Combs AC, Langer SJ, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Vera CD, et al. J Biol Chem. 2019 Nov 15;294(46):17451-17462. doi: 10.1074/jbc.RA119.010563. Epub 2019 Oct 3. J Biol Chem. 2019. PMID: 31582565 Free PMC article.

8

Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments.

Hariadi RF, Sommese RF, Adhikari AS, Taylor RE, Sutton S, Spudich JA, Sivaramakrishnan S. Hariadi RF, et al. Among authors: adhikari as. Nat Nanotechnol. 2015 Aug;10(8):696-700. doi: 10.1038/nnano.2015.132. Epub 2015 Jul 6. Nat Nanotechnol. 2015. PMID: 26149240 Free PMC article.

9

A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix.

Owen LM, Adhikari AS, Patel M, Grimmer P, Leijnse N, Kim MC, Notbohm J, Franck C, Dunn AR. Owen LM, et al. Among authors: adhikari as. Mol Biol Cell. 2017 Jul 7;28(14):1959-1974. doi: 10.1091/mbc.E17-02-0102. Epub 2017 Jun 7. Mol Biol Cell. 2017. PMID: 28592635 Free PMC article.

10

Molecular tension sensors report forces generated by single integrin molecules in living cells.

Morimatsu M, Mekhdjian AH, Adhikari AS, Dunn AR. Morimatsu M, et al. Among authors: adhikari as. Nano Lett. 2013 Sep 11;13(9):3985-9. doi: 10.1021/nl4005145. Epub 2013 Aug 28. Nano Lett. 2013. PMID: 23859772 Free PMC article.

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