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Page 1
H3K79me2/3 controls enhancer-promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells.
Godfrey L, Crump NT, O'Byrne S, Lau IJ, Rice S, Harman JR, Jackson T, Elliott N, Buck G, Connor C, Thorne R, Knapp DJHF, Heidenreich O, Vyas P, Menendez P, Inglott S, Ancliff P, Geng H, Roberts I, Roy A, Milne TA. Godfrey L, et al. Among authors: harman jr. Leukemia. 2021 Jan;35(1):90-106. doi: 10.1038/s41375-020-0808-y. Epub 2020 Apr 2. Leukemia. 2021. PMID: 32242051 Free PMC article.
Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax.
Fidyt K, Pastorczak A, Cyran J, Crump NT, Goral A, Madzio J, Muchowicz A, Poprzeczko M, Domka K, Komorowski L, Winiarska M, Harman JR, Siudakowska K, Graczyk-Jarzynka A, Patkowska E, Lech-Maranda E, Mlynarski W, Golab J, Milne TA, Firczuk M. Fidyt K, et al. Among authors: harman jr. Oncogene. 2022 Mar;41(11):1600-1609. doi: 10.1038/s41388-022-02196-y. Epub 2022 Jan 28. Oncogene. 2022. PMID: 35091682 Free PMC article.
Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development.
Owens DDG, Anselmi G, Oudelaar AM, Downes DJ, Cavallo A, Harman JR, Schwessinger R, Bucakci A, Greder L, de Ornellas S, Jeziorska D, Telenius J, Hughes JR, de Bruijn MFTR. Owens DDG, et al. Among authors: harman jr. Nat Commun. 2022 Feb 9;13(1):773. doi: 10.1038/s41467-022-28376-8. Nat Commun. 2022. PMID: 35140205 Free PMC article.
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.
Crump NT, Smith AL, Godfrey L, Dopico-Fernandez AM, Denny N, Harman JR, Hamley JC, Jackson NE, Chahrour C, Riva S, Rice S, Kim J, Basrur V, Fermin D, Elenitoba-Johnson K, Roeder RG, Allis CD, Roberts I, Roy A, Geng H, Davies JOJ, Milne TA. Crump NT, et al. Among authors: harman jr. Nat Commun. 2023 Aug 25;14(1):5208. doi: 10.1038/s41467-023-40981-9. Nat Commun. 2023. PMID: 37626123 Free PMC article.
Microhomologies are prevalent at Cas9-induced larger deletions.
Owens DDG, Caulder A, Frontera V, Harman JR, Allan AJ, Bucakci A, Greder L, Codner GF, Hublitz P, McHugh PJ, Teboul L, de Bruijn MFTR. Owens DDG, et al. Among authors: harman jr. Nucleic Acids Res. 2019 Aug 22;47(14):7402-7417. doi: 10.1093/nar/gkz459. Nucleic Acids Res. 2019. PMID: 31127293 Free PMC article.
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
Azzoni E, Frontera V, Anselmi G, Rode C, James C, Deltcheva EM, Demian AS, Brown J, Barone C, Patelli A, Harman JR, Nicholls M, Conway SJ, Morrissey E, Jacobsen SEW, Sparrow DB, Harris AL, Enver T, de Bruijn MFTR. Azzoni E, et al. Among authors: harman jr. Cell Rep. 2021 Dec 14;37(11):110103. doi: 10.1016/j.celrep.2021.110103. Cell Rep. 2021. PMID: 34910918 Free PMC article.
22 results