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Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.
Gonçalves AV, Margolis SR, Quirino GFS, Mascarenhas DPA, Rauch I, Nichols RD, Ansaldo E, Fontana MF, Vance RE, Zamboni DS. Gonçalves AV, et al. Among authors: margolis sr. PLoS Pathog. 2019 Jun 28;15(6):e1007886. doi: 10.1371/journal.ppat.1007886. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31251782 Free PMC article.
Evolutionary Origins of cGAS-STING Signaling.
Margolis SR, Wilson SC, Vance RE. Margolis SR, et al. Trends Immunol. 2017 Oct;38(10):733-743. doi: 10.1016/j.it.2017.03.004. Epub 2017 Apr 14. Trends Immunol. 2017. PMID: 28416447 Review.
Deficiency in Galectin-3, -8, and -9 impairs immunity to chronic Mycobacterium tuberculosis infection but not acute infection with multiple intracellular pathogens.
Morrison HM, Craft J, Rivera-Lugo R, Johnson JR, Golovkine GR, Bell SL, Dodd CE, Van Dis E, Beatty WL, Margolis SR, Repasy T, Shaker I, Lee AY, Vance RE, Stanley SA, Watson RO, Krogan NJ, Portnoy DA, Penn BH, Cox JS. Morrison HM, et al. Among authors: margolis sr. PLoS Pathog. 2023 Jun 23;19(6):e1011088. doi: 10.1371/journal.ppat.1011088. eCollection 2023 Jun. PLoS Pathog. 2023. PMID: 37352334 Free PMC article.
Diverse viral cas genes antagonize CRISPR immunity.
Katz MA, Sawyer EM, Oriolt L, Kozlova A, Williams MC, Margolis SR, Johnson M, Bondy-Denomy J, Meeske AJ. Katz MA, et al. Among authors: margolis sr. Nature. 2024 Oct;634(8034):677-683. doi: 10.1038/s41586-024-07923-x. Epub 2024 Sep 4. Nature. 2024. PMID: 39232173
12 results