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3-[(1S,2S,3R)-2,3-Difluoro-1-hydroxy-7-methylsulfonylindan-4-yl]oxy-5-fluorobenzonitrile (PT2977), a Hypoxia-Inducible Factor 2α (HIF-2α) Inhibitor for the Treatment of Clear Cell Renal Cell Carcinoma.
Xu R, Wang K, Rizzi JP, Huang H, Grina JA, Schlachter ST, Wang B, Wehn PM, Yang H, Dixon DD, Czerwinski RM, Du X, Ged EL, Han G, Tan H, Wong T, Xie S, Josey JA, Wallace EM. Xu R, et al. Among authors: tan h. J Med Chem. 2019 Aug 8;62(15):6876-6893. doi: 10.1021/acs.jmedchem.9b00719. Epub 2019 Jul 8. J Med Chem. 2019. PMID: 31282155 Clinical Trial.
A Small-Molecule Antagonist of HIF2α Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Wallace EM, Rizzi JP, Han G, Wehn PM, Cao Z, Du X, Cheng T, Czerwinski RM, Dixon DD, Goggin BS, Grina JA, Halfmann MM, Maddie MA, Olive SR, Schlachter ST, Tan H, Wang B, Wang K, Xie S, Xu R, Yang H, Josey JA. Wallace EM, et al. Among authors: tan h. Cancer Res. 2016 Sep 15;76(18):5491-500. doi: 10.1158/0008-5472.CAN-16-0473. Epub 2016 Sep 6. Cancer Res. 2016. PMID: 27635045
Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate ( S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385).
Wehn PM, Rizzi JP, Dixon DD, Grina JA, Schlachter ST, Wang B, Xu R, Yang H, Du X, Han G, Wang K, Cao Z, Cheng T, Czerwinski RM, Goggin BS, Huang H, Halfmann MM, Maddie MA, Morton EL, Olive SR, Tan H, Xie S, Wong T, Josey JA, Wallace EM. Wehn PM, et al. Among authors: tan h. J Med Chem. 2018 Nov 8;61(21):9691-9721. doi: 10.1021/acs.jmedchem.8b01196. Epub 2018 Oct 18. J Med Chem. 2018. PMID: 30289716
Tumor-targeted delivery of a STING agonist improvescancer immunotherapy.
Wu YT, Fang Y, Wei Q, Shi H, Tan H, Deng Y, Zeng Z, Qiu J, Chen C, Sun L, Chen ZJ. Wu YT, et al. Among authors: tan h. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2214278119. doi: 10.1073/pnas.2214278119. Epub 2022 Nov 29. Proc Natl Acad Sci U S A. 2022. PMID: 36442099 Free PMC article.
Cortico-thalamic tremor circuits and their associations with deep brain stimulation effects in essential tremor.
He S, West TO, Plazas FR, Wehmeyer L, Pogosyan A, Deli A, Wiest C, Herz DM, Simpson T, Andrade P, Baig F, Hart MG, Morgante F, FitzGerald JJ, Barbe MT, Visser-Vandewalle V, Green AL, Pereira EA, Cagnan H, Tan H. He S, et al. Among authors: tan h. Brain. 2024 Nov 27:awae387. doi: 10.1093/brain/awae387. Online ahead of print. Brain. 2024. PMID: 39592428
Resonance-Amplified Terahertz Near-Field Spectroscopy of a Single Nanowire.
Norman S, Chu G, Peng K, Seddon J, Hale LL, Tan HH, Jagadish C, Mouthaan R, Alexander-Webber J, Joyce HJ, Johnston MB, Mitrofanov O, Siday T. Norman S, et al. Among authors: tan hh. Nano Lett. 2024 Nov 26. doi: 10.1021/acs.nanolett.4c04395. Online ahead of print. Nano Lett. 2024. PMID: 39588607
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