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Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.
Anantharajan J, Zhou H, Zhang L, Hotz T, Vincent MY, Blevins MA, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Baburajendran N, Lin G, Hung AW, Joy J, Patnaik S, Marugan J, Rudra P, Ghosh D, Hill J, Keller TH, Zhao R, Ford HL, Kang C. Anantharajan J, et al. Among authors: ford hl. Mol Cancer Ther. 2019 Sep;18(9):1484-1496. doi: 10.1158/1535-7163.MCT-18-1239. Epub 2019 Jul 8. Mol Cancer Ther. 2019. PMID: 31285279 Free PMC article.
The six family of homeobox genes in development and cancer.
Christensen KL, Patrick AN, McCoy EL, Ford HL. Christensen KL, et al. Among authors: ford hl. Adv Cancer Res. 2008;101:93-126. doi: 10.1016/S0065-230X(08)00405-3. Adv Cancer Res. 2008. PMID: 19055944 Review.
CDK6 binds and promotes the degradation of the EYA2 protein.
Kohrt D, Crary J, Zimmer M, Patrick AN, Ford HL, Hinds PW, Grossel MJ. Kohrt D, et al. Among authors: ford hl. Cell Cycle. 2014;13(1):62-71. doi: 10.4161/cc.26755. Epub 2013 Oct 12. Cell Cycle. 2014. PMID: 24196439 Free PMC article.
Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.
Krueger AB, Drasin DJ, Lea WA, Patrick AN, Patnaik S, Backos DS, Matheson CJ, Hu X, Barnaeva E, Holliday MJ, Blevins MA, Robin TP, Eisenmesser EZ, Ferrer M, Simeonov A, Southall N, Reigan P, Marugan J, Ford HL, Zhao R. Krueger AB, et al. Among authors: ford hl. J Biol Chem. 2014 Jun 6;289(23):16349-61. doi: 10.1074/jbc.M114.566729. Epub 2014 Apr 22. J Biol Chem. 2014. PMID: 24755226 Free PMC article.
The SIX1-EYA transcriptional complex as a therapeutic target in cancer.
Blevins MA, Towers CG, Patrick AN, Zhao R, Ford HL. Blevins MA, et al. Among authors: ford hl. Expert Opin Ther Targets. 2015 Feb;19(2):213-25. doi: 10.1517/14728222.2014.978860. Epub 2015 Jan 2. Expert Opin Ther Targets. 2015. PMID: 25555392 Free PMC article. Review.
153 results