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Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes.
Martinov T, Swanson LA, Breed ER, Tucker CG, Dwyer AJ, Johnson JK, Mitchell JS, Sahli NL, Wilson JC, Singh LM, Hogquist KA, Spanier JA, Fife BT. Martinov T, et al. Among authors: dwyer aj. J Immunol. 2019 Aug 15;203(4):844-852. doi: 10.4049/jimmunol.1801535. Epub 2019 Jul 19. J Immunol. 2019. PMID: 31324724 Free PMC article.
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.
Dirice E, Kahraman S, De Jesus DF, El Ouaamari A, Basile G, Baker RL, Yigit B, Piehowski PD, Kim MJ, Dwyer AJ, Ng RWS, Schuster C, Vethe H, Martinov T, Ishikawa Y, Teo AKK, Smith RD, Hu J, Haskins K, Serwold T, Qian WJ, Fife BT, Kissler S, Kulkarni RN. Dirice E, et al. Among authors: dwyer aj. Nat Metab. 2019 May;1(5):509-518. doi: 10.1038/s42255-019-0061-8. Epub 2019 May 6. Nat Metab. 2019. PMID: 31423480 Free PMC article.
Adoptive T Cell Therapy with IL-12-Preconditioned Low-Avidity T Cells Prevents Exhaustion and Results in Enhanced T Cell Activation, Enhanced Tumor Clearance, and Decreased Risk for Autoimmunity.
Tucker CG, Mitchell JS, Martinov T, Burbach BJ, Beura LK, Wilson JC, Dwyer AJ, Singh LM, Mescher MF, Fife BT. Tucker CG, et al. Among authors: dwyer aj. J Immunol. 2020 Sep 1;205(5):1449-1460. doi: 10.4049/jimmunol.2000007. Epub 2020 Jul 31. J Immunol. 2020. PMID: 32737148 Free PMC article.
The Role of Programmed Death-1 in Type 1 Diabetes.
Tucker CG, Dwyer AJ, Fife BT, Martinov T. Tucker CG, et al. Among authors: dwyer aj. Curr Diab Rep. 2021 May 6;21(6):20. doi: 10.1007/s11892-021-01384-6. Curr Diab Rep. 2021. PMID: 33956235 Free PMC article. Review.
Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes.
Spanier JA, Fung V, Wardell CM, Alkhatib MH, Chen Y, Swanson LA, Dwyer AJ, Weno ME, Silva N, Mitchell JS, Orban PC, Mojibian M, Verchere CB, Fife BT, Levings MK. Spanier JA, et al. Among authors: dwyer aj. bioRxiv [Preprint]. 2023 Feb 24:2023.02.23.529737. doi: 10.1101/2023.02.23.529737. bioRxiv. 2023. Update in: J Clin Invest. 2023 Sep 15;133(18):e168601. doi: 10.1172/JCI168601 PMID: 36865264 Free PMC article. Updated. Preprint.
Antigen-specific T cell responses in autoimmune diabetes.
Dwyer AJ, Shaheen ZR, Fife BT. Dwyer AJ, et al. Front Immunol. 2024 Aug 15;15:1440045. doi: 10.3389/fimmu.2024.1440045. eCollection 2024. Front Immunol. 2024. PMID: 39211046 Free PMC article. Review.
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes.
Mitchell JS, Spanier JA, Dwyer AJ, Knutson TP, Alkhatib MH, Qian G, Weno ME, Chen Y, Shaheen ZR, Tucker CG, Kangas TO, Morales MS, Silva N, Kaisho T, Farrar MA, Fife BT. Mitchell JS, et al. Among authors: dwyer aj. Immunity. 2024 Oct 8;57(10):2399-2415.e8. doi: 10.1016/j.immuni.2024.07.024. Epub 2024 Aug 29. Immunity. 2024. PMID: 39214091
152 results