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Page 1
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response.
Antunes KH, Fachi JL, de Paula R, da Silva EF, Pral LP, Dos Santos AÁ, Dias GBM, Vargas JE, Puga R, Mayer FQ, Maito F, Zárate-Bladés CR, Ajami NJ, Sant'Ana MR, Candreva T, Rodrigues HG, Schmiele M, Silva Clerici MTP, Proença-Modena JL, Vieira AT, Mackay CR, Mansur D, Caballero MT, Marzec J, Li J, Wang X, Bell D, Polack FP, Kleeberger SR, Stein RT, Vinolo MAR, de Souza APD. Antunes KH, et al. Among authors: fachi jl. Nat Commun. 2019 Jul 22;10(1):3273. doi: 10.1038/s41467-019-11152-6. Nat Commun. 2019. PMID: 31332169 Free PMC article.
Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases.
Fellows R, Denizot J, Stellato C, Cuomo A, Jain P, Stoyanova E, Balázsi S, Hajnády Z, Liebert A, Kazakevych J, Blackburn H, Corrêa RO, Fachi JL, Sato FT, Ribeiro WR, Ferreira CM, Perée H, Spagnuolo M, Mattiuz R, Matolcsi C, Guedes J, Clark J, Veldhoen M, Bonaldi T, Vinolo MAR, Varga-Weisz P. Fellows R, et al. Among authors: fachi jl. Nat Commun. 2018 Jan 9;9(1):105. doi: 10.1038/s41467-017-02651-5. Nat Commun. 2018. PMID: 29317660 Free PMC article.
The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung.
Galvão I, Tavares LP, Corrêa RO, Fachi JL, Rocha VM, Rungue M, Garcia CC, Cassali G, Ferreira CM, Martins FS, Oliveira SC, Mackay CR, Teixeira MM, Vinolo MAR, Vieira AT. Galvão I, et al. Among authors: fachi jl. Front Immunol. 2018 Feb 20;9:142. doi: 10.3389/fimmu.2018.00142. eCollection 2018. Front Immunol. 2018. PMID: 29515566 Free PMC article.
Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism.
Fachi JL, Felipe JS, Pral LP, da Silva BK, Corrêa RO, de Andrade MCP, da Fonseca DM, Basso PJ, Câmara NOS, de Sales E Souza ÉL, Dos Santos Martins F, Guima SES, Thomas AM, Setubal JC, Magalhães YT, Forti FL, Candreva T, Rodrigues HG, de Jesus MB, Consonni SR, Farias ADS, Varga-Weisz P, Vinolo MAR. Fachi JL, et al. Cell Rep. 2019 Apr 16;27(3):750-761.e7. doi: 10.1016/j.celrep.2019.03.054. Cell Rep. 2019. PMID: 30995474 Free article.
Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2.
Fachi JL, Sécca C, Rodrigues PB, Mato FCP, Di Luccia B, Felipe JS, Pral LP, Rungue M, Rocha VM, Sato FT, Sampaio U, Clerici MTPS, Rodrigues HG, Câmara NOS, Consonni SR, Vieira AT, Oliveira SC, Mackay CR, Layden BT, Bortoluci KR, Colonna M, Vinolo MAR. Fachi JL, et al. J Exp Med. 2020 Mar 2;217(3):jem.20190489. doi: 10.1084/jem.20190489. J Exp Med. 2020. PMID: 31876919 Free PMC article.
Hypoxia enhances ILC3 responses through HIF-1α-dependent mechanism.
Fachi JL, Pral LP, Dos Santos JAC, Codo AC, de Oliveira S, Felipe JS, Zambom FFF, Câmara NOS, Vieira PMMM, Colonna M, Vinolo MAR. Fachi JL, et al. Mucosal Immunol. 2021 Jul;14(4):828-841. doi: 10.1038/s41385-020-00371-6. Epub 2021 Jan 14. Mucosal Immunol. 2021. PMID: 33446906 Free PMC article.
Short-chain fatty acid acetate triggers antiviral response mediated by RIG-I in cells from infants with respiratory syncytial virus bronchiolitis.
Antunes KH, Stein RT, Franceschina C, da Silva EF, de Freitas DN, Silveira J, Mocellin M, Leitão L, Fachi JL, Pral LP, Gonzalez A, Oliveira S, Duarte L, Cassão G, Gonçalves JIB, Reis TM, Abbadi BL, Dornelles M, Sperotto NDM, Rigo M, Rodrigues H, Jones M, Epifanio M, Guima S, Setubal JC, Jorge TR, Mansur DS, Mayer FQ, Varela APM, Bizarro CV, Machado P, Basso LA, Polack FP, Custovic A, Vinolo MAR, de Souza APD. Antunes KH, et al. Among authors: fachi jl. EBioMedicine. 2022 Mar;77:103891. doi: 10.1016/j.ebiom.2022.103891. Epub 2022 Feb 24. EBioMedicine. 2022. PMID: 35220042 Free PMC article.
Neutrophil-Derived COX-2 has a Key Role during Inflammatory Hyperalgesia.
Carvalho NS, Lemes JBP, Pagliusi M Jr, Machado ACDS, Malange KF, Pral LP, Fachi JL, Nishijima CM, Dos Santos GG, Tambeli CH, Sartori CR, Vinolo MAR, Parada CA. Carvalho NS, et al. Among authors: fachi jl. Inflammation. 2022 Dec;45(6):2280-2293. doi: 10.1007/s10753-022-01690-5. Epub 2022 Jul 15. Inflammation. 2022. PMID: 35840810
33 results