Holt JR - Search Results

1

Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Thuronyi BW, et al. Among authors: holt jr. Nat Biotechnol. 2019 Sep;37(9):1070-1079. doi: 10.1038/s41587-019-0193-0. Epub 2019 Jul 22. Nat Biotechnol. 2019. PMID: 31332326 Free PMC article.

2

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear.

Landegger LD, Pan B, Askew C, Wassmer SJ, Gluck SD, Galvin A, Taylor R, Forge A, Stankovic KM, Holt JR, Vandenberghe LH. Landegger LD, et al. Among authors: holt jr. Nat Biotechnol. 2017 Mar;35(3):280-284. doi: 10.1038/nbt.3781. Epub 2017 Feb 6. Nat Biotechnol. 2017. PMID: 28165475 Free PMC article.

3

Emerging Gene Therapies for Genetic Hearing Loss.

Ahmed H, Shubina-Oleinik O, Holt JR. Ahmed H, et al. Among authors: holt jr. J Assoc Res Otolaryngol. 2017 Oct;18(5):649-670. doi: 10.1007/s10162-017-0634-8. Epub 2017 Aug 16. J Assoc Res Otolaryngol. 2017. PMID: 28815315 Free PMC article. Review.

4

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.

Gao X, Tao Y, Lamas V, Huang M, Yeh WH, Pan B, Hu YJ, Hu JH, Thompson DB, Shu Y, Li Y, Wang H, Yang S, Xu Q, Polley DB, Liberman MC, Kong WJ, Holt JR, Chen ZY, Liu DR. Gao X, et al. Among authors: holt jr. Nature. 2018 Jan 11;553(7687):217-221. doi: 10.1038/nature25164. Epub 2017 Dec 20. Nature. 2018. PMID: 29258297 Free PMC article.

5

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.

György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. György B, et al. Among authors: holt jr. Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270503 Free PMC article.

6

Publisher Correction: Continuous evolution of base editors with expanded target compatibility and improved activity.

Thuronyi BW, Koblan LW, Levy JM, Yeh WH, Zheng C, Newby GA, Wilson C, Bhaumik M, Shubina-Oleinik O, Holt JR, Liu DR. Thuronyi BW, et al. Among authors: holt jr. Nat Biotechnol. 2019 Sep;37(9):1091. doi: 10.1038/s41587-019-0253-5. Nat Biotechnol. 2019. PMID: 31406330

7

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness.

Yeh WH, Shubina-Oleinik O, Levy JM, Pan B, Newby GA, Wornow M, Burt R, Chen JC, Holt JR, Liu DR. Yeh WH, et al. Among authors: holt jr. Sci Transl Med. 2020 Jun 3;12(546):eaay9101. doi: 10.1126/scitranslmed.aay9101. Sci Transl Med. 2020. PMID: 32493795 Free PMC article.

8

Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice.

Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR. Wu J, et al. Among authors: holt jr. Mol Ther. 2021 Mar 3;29(3):973-988. doi: 10.1016/j.ymthe.2020.11.016. Epub 2020 Nov 17. Mol Ther. 2021. PMID: 33212302 Free PMC article.

9

Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.

Shubina-Oleinik O, Nist-Lund C, French C, Rockowitz S, Shearer AE, Holt JR. Shubina-Oleinik O, et al. Among authors: holt jr. Sci Adv. 2021 Dec 17;7(51):eabi7629. doi: 10.1126/sciadv.abi7629. Epub 2021 Dec 15. Sci Adv. 2021. PMID: 34910522 Free PMC article.

10

Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11.

Marcovich I, Baer NK, Shubina-Oleinik O, Eclov R, Beard CW, Holt JR. Marcovich I, et al. Among authors: holt jr. Biomolecules. 2022 Jun 29;12(7):914. doi: 10.3390/biom12070914. Biomolecules. 2022. PMID: 35883470 Free PMC article.

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