Whitworth AJ - Search Results

1

Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila.

Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, Whitworth AJ. Andreazza S, et al. Among authors: whitworth aj. Nat Commun. 2019 Jul 23;10(1):3280. doi: 10.1038/s41467-019-10857-y. Nat Commun. 2019. PMID: 31337756 Free PMC article.

2

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants.

Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ. Greene JC, et al. Among authors: whitworth aj. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4078-83. doi: 10.1073/pnas.0737556100. Epub 2003 Mar 17. Proc Natl Acad Sci U S A. 2003. PMID: 12642658 Free PMC article.

3

Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis.

Greene JC, Whitworth AJ, Andrews LA, Parker TJ, Pallanck LJ. Greene JC, et al. Among authors: whitworth aj. Hum Mol Genet. 2005 Mar 15;14(6):799-811. doi: 10.1093/hmg/ddi074. Epub 2005 Feb 2. Hum Mol Genet. 2005. PMID: 15689351

4

A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage.

Jackson SM, Whitworth AJ, Greene JC, Libby RT, Baccam SL, Pallanck LJ, La Spada AR. Jackson SM, et al. Among authors: whitworth aj. Gene. 2005 Feb 28;347(1):35-41. doi: 10.1016/j.gene.2004.12.008. Gene. 2005. PMID: 15715978

5

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.

Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ. Whitworth AJ, et al. Proc Natl Acad Sci U S A. 2005 May 31;102(22):8024-9. doi: 10.1073/pnas.0501078102. Epub 2005 May 23. Proc Natl Acad Sci U S A. 2005. PMID: 15911761 Free PMC article.

6

Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.

Meulener M, Whitworth AJ, Armstrong-Gold CE, Rizzu P, Heutink P, Wes PD, Pallanck LJ, Bonini NM. Meulener M, et al. Among authors: whitworth aj. Curr Biol. 2005 Sep 6;15(17):1572-7. doi: 10.1016/j.cub.2005.07.064. Curr Biol. 2005. PMID: 16139213 Free article.

7

Drosophila models pioneer a new approach to drug discovery for Parkinson's disease.

Whitworth AJ, Wes PD, Pallanck LJ. Whitworth AJ, et al. Drug Discov Today. 2006 Feb;11(3-4):119-26. doi: 10.1016/S1359-6446(05)03693-7. Drug Discov Today. 2006. PMID: 16533709 Review.

8

The PINK1/Parkin pathway regulates mitochondrial morphology.

Poole AC, Thomas RE, Andrews LA, McBride HM, Whitworth AJ, Pallanck LJ. Poole AC, et al. Among authors: whitworth aj. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1638-43. doi: 10.1073/pnas.0709336105. Epub 2008 Jan 29. Proc Natl Acad Sci U S A. 2008. PMID: 18230723 Free PMC article.

9

Genetic models of Parkinson's disease: mechanisms and therapies.

Whitworth AJ, Pallanck LJ. Whitworth AJ, et al. SEB Exp Biol Ser. 2008;60:93-113. SEB Exp Biol Ser. 2008. PMID: 18309789 Review. No abstract available.

10

The PINK1/Parkin pathway: a mitochondrial quality control system?

Whitworth AJ, Pallanck LJ. Whitworth AJ, et al. J Bioenerg Biomembr. 2009 Dec;41(6):499-503. doi: 10.1007/s10863-009-9253-3. J Bioenerg Biomembr. 2009. PMID: 19967438 Free article. Review.

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