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G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo.
Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, Woodling NS, Niccoli T, Gilbert-Jaramillo J, Abdelkarim S, Clayton EL, Clarke M, Konrad MT, Nicoll AJ, Mitchell JS, Calvo A, Chio A, Houlden H, Polke JM, Ismail MA, Stephens CE, Vo T, Farahat AA, Wilson WD, Boykin DW, Zetterberg H, Partridge L, Wray S, Parkinson G, Neidle S, Patani R, Fratta P, Isaacs AM. Simone R, et al. Among authors: mitchell js. EMBO Mol Med. 2018 Jan;10(1):22-31. doi: 10.15252/emmm.201707850. EMBO Mol Med. 2018. PMID: 29113975 Free PMC article.
Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering.
Maffioletti SM, Sarcar S, Henderson ABH, Mannhardt I, Pinton L, Moyle LA, Steele-Stallard H, Cappellari O, Wells KE, Ferrari G, Mitchell JS, Tyzack GE, Kotiadis VN, Khedr M, Ragazzi M, Wang W, Duchen MR, Patani R, Zammit PS, Wells DJ, Eschenhagen T, Tedesco FS. Maffioletti SM, et al. Among authors: mitchell js. Cell Rep. 2018 Apr 17;23(3):899-908. doi: 10.1016/j.celrep.2018.03.091. Cell Rep. 2018. PMID: 29669293 Free PMC article.
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.
Luisier R, Tyzack GE, Hall CE, Mitchell JS, Devine H, Taha DM, Malik B, Meyer I, Greensmith L, Newcombe J, Ule J, Luscombe NM, Patani R. Luisier R, et al. Among authors: mitchell js. Nat Commun. 2018 May 22;9(1):2010. doi: 10.1038/s41467-018-04373-8. Nat Commun. 2018. PMID: 29789581 Free PMC article.
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration.
Simone R, Javad F, Emmett W, Wilkins OG, Almeida FL, Barahona-Torres N, Zareba-Paslawska J, Ehteramyan M, Zuccotti P, Modelska A, Siva K, Virdi GS, Mitchell JS, Harley J, Kay VA, Hondhamuni G, Trabzuni D, Ryten M, Wray S, Preza E, Kia DA, Pittman A, Ferrari R, Manzoni C, Lees A, Hardy JA, Denti MA, Quattrone A, Patani R, Svenningsson P, Warner TT, Plagnol V, Ule J, de Silva R. Simone R, et al. Among authors: mitchell js. Nature. 2021 Jun;594(7861):117-123. doi: 10.1038/s41586-021-03556-6. Epub 2021 May 19. Nature. 2021. PMID: 34012113 Free PMC article.
Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD.
Moens TG, Mizielinska S, Niccoli T, Mitchell JS, Thoeng A, Ridler CE, Grönke S, Esser J, Heslegrave A, Zetterberg H, Partridge L, Isaacs AM. Moens TG, et al. Among authors: mitchell js. Acta Neuropathol. 2018 Mar;135(3):445-457. doi: 10.1007/s00401-017-1798-3. Epub 2018 Jan 29. Acta Neuropathol. 2018. PMID: 29380049 Free PMC article.
188 results