Tyndall JDA - Search Results

1

Structure-activity analysis of peptidic Chlamydia HtrA inhibitors.

Agbowuro AA, Hwang J, Peel E, Mazraani R, Springwald A, Marsh JW, McCaughey L, Gamble AB, Huston WM, Tyndall JDA. Agbowuro AA, et al. Among authors: tyndall jda. Bioorg Med Chem. 2019 Sep 15;27(18):4185-4199. doi: 10.1016/j.bmc.2019.07.049. Epub 2019 Jul 30. Bioorg Med Chem. 2019. PMID: 31395511

2

Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis.

Huston WM, Tyndall JD, Lott WB, Stansfield SH, Timms P. Huston WM, et al. PLoS One. 2011;6(9):e24547. doi: 10.1371/journal.pone.0024547. Epub 2011 Sep 8. PLoS One. 2011. PMID: 21931748 Free PMC article.

3

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA).

Matthews H, Ranson M, Tyndall JD, Kelso MJ. Matthews H, et al. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6760-6. doi: 10.1016/j.bmcl.2011.09.044. Epub 2011 Sep 18. Bioorg Med Chem Lett. 2011. PMID: 21978672

4

the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions.

Gloeckl S, Tyndall JD, Stansfield SH, Timms P, Huston WM. Gloeckl S, et al. J Mol Microbiol Biotechnol. 2012;22(1):10-6. doi: 10.1159/000336312. Epub 2012 Feb 21. J Mol Microbiol Biotechnol. 2012. PMID: 22353774 Free article.

5

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, Bogyo M, Huston WM. Gloeckl S, et al. Mol Microbiol. 2013 Aug;89(4):676-89. doi: 10.1111/mmi.12306. Epub 2013 Jul 12. Mol Microbiol. 2013. PMID: 23796320 Free article.

6

Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5.

Marsh JW, Lott WB, Tyndall JD, Huston WW. Marsh JW, et al. Cell Mol Biol Lett. 2013 Dec;18(4):522-37. doi: 10.2478/s11658-013-0103-2. Epub 2013 Sep 13. Cell Mol Biol Lett. 2013. PMID: 24036669 Free PMC article.

7

Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor.

Spencer ES, Dale EJ, Gommans AL, Rutledge MT, Vo CT, Nakatani Y, Gamble AB, Smith RA, Wilbanks SM, Hampton MB, Tyndall JD. Spencer ES, et al. Eur J Med Chem. 2015 Mar 26;93:501-10. doi: 10.1016/j.ejmech.2015.02.012. Epub 2015 Feb 24. Eur J Med Chem. 2015. PMID: 25743213

8

A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.

Marsh JW, Wee BA, Tyndall JD, Lott WB, Bastidas RJ, Caldwell HD, Valdivia RH, Kari L, Huston WM. Marsh JW, et al. BMC Microbiol. 2015 Sep 30;15:194. doi: 10.1186/s12866-015-0533-2. BMC Microbiol. 2015. PMID: 26424482 Free PMC article.

9

Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.

Lawrence A, Fraser T, Gillett A, Tyndall JD, Timms P, Polkinghorne A, Huston WM. Lawrence A, et al. Sci Rep. 2016 Aug 17;6:31466. doi: 10.1038/srep31466. Sci Rep. 2016. PMID: 27530689 Free PMC article.

10

Stability, Kinetic, and Mechanistic Investigation of 1,8-Self-Immolative Cinnamyl Ether Spacers for Controlled Release of Phenols and Generation of Resonance and Inductively Stabilized Methides.

Matikonda SS, Fairhall JM, Tyndall JD, Hook S, Gamble AB. Matikonda SS, et al. Org Lett. 2017 Feb 3;19(3):528-531. doi: 10.1021/acs.orglett.6b03695. Epub 2017 Jan 12. Org Lett. 2017. PMID: 28080067

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