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Page 1
Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3-Knockin Mice.
Burova E, Hermann A, Dai J, Ullman E, Halasz G, Potocky T, Hong S, Liu M, Allbritton O, Woodruff A, Pei J, Rafique A, Poueymirou W, Martin J, MacDonald D, Olson WC, Murphy A, Ioffe E, Thurston G, Mohrs M. Burova E, et al. Among authors: ioffe e. Mol Cancer Ther. 2019 Nov;18(11):2051-2062. doi: 10.1158/1535-7163.MCT-18-1376. Epub 2019 Aug 8. Mol Cancer Ther. 2019. PMID: 31395688
Characterization of the Anti-PD-1 Antibody REGN2810 and Its Antitumor Activity in Human PD-1 Knock-In Mice.
Burova E, Hermann A, Waite J, Potocky T, Lai V, Hong S, Liu M, Allbritton O, Woodruff A, Wu Q, D'Orvilliers A, Garnova E, Rafique A, Poueymirou W, Martin J, Huang T, Skokos D, Kantrowitz J, Popke J, Mohrs M, MacDonald D, Ioffe E, Olson W, Lowy I, Murphy A, Thurston G. Burova E, et al. Among authors: ioffe e. Mol Cancer Ther. 2017 May;16(5):861-870. doi: 10.1158/1535-7163.MCT-16-0665. Epub 2017 Mar 6. Mol Cancer Ther. 2017. PMID: 28265006
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells.
Daly C, Pasnikowski E, Burova E, Wong V, Aldrich TH, Griffiths J, Ioffe E, Daly TJ, Fandl JP, Papadopoulos N, McDonald DM, Thurston G, Yancopoulos GD, Rudge JS. Daly C, et al. Among authors: ioffe e. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15491-6. doi: 10.1073/pnas.0607538103. Epub 2006 Oct 9. Proc Natl Acad Sci U S A. 2006. PMID: 17030814 Free PMC article.
The anti-inflammatory actions of angiopoietin-1.
Thurston G, Rudge JS, Ioffe E, Papadopoulos N, Daly C, Vuthoori S, Daly T, Wiegand SJ, Yancopoulos GD. Thurston G, et al. Among authors: ioffe e. EXS. 2005;(94):233-45. doi: 10.1007/3-7643-7311-3_16. EXS. 2005. PMID: 15617482 Review. No abstract available.
VEGF-Trap: a VEGF blocker with potent antitumor effects.
Holash J, Davis S, Papadopoulos N, Croll SD, Ho L, Russell M, Boland P, Leidich R, Hylton D, Burova E, Ioffe E, Huang T, Radziejewski C, Bailey K, Fandl JP, Daly T, Wiegand SJ, Yancopoulos GD, Rudge JS. Holash J, et al. Among authors: ioffe e. Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11393-8. doi: 10.1073/pnas.172398299. Epub 2002 Aug 12. Proc Natl Acad Sci U S A. 2002. PMID: 12177445 Free PMC article.
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering.
Davis S, Papadopoulos N, Aldrich TH, Maisonpierre PC, Huang T, Kovac L, Xu A, Leidich R, Radziejewska E, Rafique A, Goldberg J, Jain V, Bailey K, Karow M, Fandl J, Samuelsson SJ, Ioffe E, Rudge JS, Daly TJ, Radziejewski C, Yancopoulos GD. Davis S, et al. Among authors: ioffe e. Nat Struct Biol. 2003 Jan;10(1):38-44. doi: 10.1038/nsb880. Nat Struct Biol. 2003. PMID: 12469114
40 results