Holstein SA - Search Results

1

In Vivo Evaluation of Isoprenoid Triazole Bisphosphonate Inhibitors of Geranylgeranyl Diphosphate Synthase: Impact of Olefin Stereochemistry on Toxicity and Biodistribution.

Haney SL, Chhonker YS, Varney ML, Talmon G, Smith LM, Murry DJ, Holstein SA. Haney SL, et al. Among authors: holstein sa. J Pharmacol Exp Ther. 2019 Nov;371(2):327-338. doi: 10.1124/jpet.119.258624. Epub 2019 Aug 16. J Pharmacol Exp Ther. 2019. PMID: 31420526 Free PMC article.

2

Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies.

Holstein SA, Knapp HR, Clamon GH, Murry DJ, Hohl RJ. Holstein SA, et al. Cancer Chemother Pharmacol. 2006 Jan;57(2):155-64. doi: 10.1007/s00280-005-0013-8. Epub 2005 Aug 30. Cancer Chemother Pharmacol. 2006. PMID: 16133537 Clinical Trial.

3

Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.

Zhou X, Ferree SD, Wills VS, Born EJ, Tong H, Wiemer DF, Holstein SA. Zhou X, et al. Among authors: holstein sa. Bioorg Med Chem. 2014 May 1;22(9):2791-8. doi: 10.1016/j.bmc.2014.03.014. Epub 2014 Mar 24. Bioorg Med Chem. 2014. PMID: 24726306 Free PMC article.

4

A new motif for inhibitors of geranylgeranyl diphosphate synthase.

Foust BJ, Allen C, Holstein SA, Wiemer DF. Foust BJ, et al. Among authors: holstein sa. Bioorg Med Chem. 2016 Aug 15;24(16):3734-41. doi: 10.1016/j.bmc.2016.06.019. Epub 2016 Jun 10. Bioorg Med Chem. 2016. PMID: 27338660 Free PMC article.

5

Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates.

Matthiesen RA, Wills VS, Metzger JI, Holstein SA, Wiemer DF. Matthiesen RA, et al. Among authors: holstein sa. J Org Chem. 2016 Oct 7;81(19):9438-9442. doi: 10.1021/acs.joc.6b01693. Epub 2016 Sep 20. J Org Chem. 2016. PMID: 27648672 Free PMC article.

6

Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase.

Allen C, Kortagere S, Tong H, Matthiesen RA, Metzger JI, Wiemer DF, Holstein SA. Allen C, et al. Among authors: holstein sa. Mol Pharmacol. 2017 Mar;91(3):229-236. doi: 10.1124/mol.116.107326. Epub 2017 Jan 5. Mol Pharmacol. 2017. PMID: 28057800 Free PMC article.

7

Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase.

Wills VS, Metzger JI, Allen C, Varney ML, Wiemer DF, Holstein SA. Wills VS, et al. Among authors: holstein sa. Bioorg Med Chem. 2017 Apr 15;25(8):2437-2444. doi: 10.1016/j.bmc.2017.02.066. Epub 2017 Mar 4. Bioorg Med Chem. 2017. PMID: 28302510 Free PMC article.

8

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors.

Haney SL, Wills VS, Wiemer DF, Holstein SA. Haney SL, et al. Among authors: holstein sa. Molecules. 2017 May 27;22(6):886. doi: 10.3390/molecules22060886. Molecules. 2017. PMID: 28555000 Free PMC article. Review.

9

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells.

Haney SL, Allen C, Varney ML, Dykstra KM, Falcone ER, Colligan SH, Hu Q, Aldridge AM, Wright DL, Wiemer AJ, Holstein SA. Haney SL, et al. Among authors: holstein sa. Oncotarget. 2017 Jun 16;8(44):76085-76098. doi: 10.18632/oncotarget.18543. eCollection 2017 Sep 29. Oncotarget. 2017. PMID: 29100294 Free PMC article.

10

α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors.

Matthiesen RA, Varney ML, Xu PC, Rier AS, Wiemer DF, Holstein SA. Matthiesen RA, et al. Among authors: holstein sa. Bioorg Med Chem. 2018 Jan 15;26(2):376-385. doi: 10.1016/j.bmc.2017.10.023. Epub 2017 Oct 19. Bioorg Med Chem. 2018. PMID: 29248353 Free PMC article.

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