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Therapeutic blockade of activin-A improves NK cell function and antitumor immunity.
Rautela J, Dagley LF, de Oliveira CC, Schuster IS, Hediyeh-Zadeh S, Delconte RB, Cursons J, Hennessy R, Hutchinson DS, Harrison C, Kita B, Vivier E, Webb AI, Degli-Esposti MA, Davis MJ, Huntington ND, Souza-Fonseca-Guimaraes F. Rautela J, et al. Sci Signal. 2019 Aug 27;12(596):eaat7527. doi: 10.1126/scisignal.aat7527. Sci Signal. 2019. PMID: 31455725
Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells.
Sathe P, Delconte RB, Souza-Fonseca-Guimaraes F, Seillet C, Chopin M, Vandenberg CJ, Rankin LC, Mielke LA, Vikstrom I, Kolesnik TB, Nicholson SE, Vivier E, Smyth MJ, Nutt SL, Glaser SP, Strasser A, Belz GT, Carotta S, Huntington ND. Sathe P, et al. Nat Commun. 2014 Aug 14;5:4539. doi: 10.1038/ncomms5539. Nat Commun. 2014. PMID: 25119382 Free article.
DNAM-1 expression marks an alternative program of NK cell maturation.
Martinet L, Ferrari De Andrade L, Guillerey C, Lee JS, Liu J, Souza-Fonseca-Guimaraes F, Hutchinson DS, Kolesnik TB, Nicholson SE, Huntington ND, Smyth MJ. Martinet L, et al. Cell Rep. 2015 Apr 7;11(1):85-97. doi: 10.1016/j.celrep.2015.03.006. Epub 2015 Mar 26. Cell Rep. 2015. PMID: 25818301 Free article.
NK cells require IL-28R for optimal in vivo activity.
Souza-Fonseca-Guimaraes F, Young A, Mittal D, Martinet L, Bruedigam C, Takeda K, Andoniou CE, Degli-Esposti MA, Hill GR, Smyth MJ. Souza-Fonseca-Guimaraes F, et al. Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2376-84. doi: 10.1073/pnas.1424241112. Epub 2015 Apr 21. Proc Natl Acad Sci U S A. 2015. PMID: 25901316 Free PMC article.
Bench to bedside: NK cells and control of metastasis.
Krasnova Y, Putz EM, Smyth MJ, Souza-Fonseca-Guimaraes F. Krasnova Y, et al. Clin Immunol. 2017 Apr;177:50-59. doi: 10.1016/j.clim.2015.10.001. Epub 2015 Oct 23. Clin Immunol. 2017. PMID: 26476139 Review.
Granzyme M has a critical role in providing innate immune protection in ulcerative colitis.
Souza-Fonseca-Guimaraes F, Krasnova Y, Putoczki T, Miles K, MacDonald KP, Town L, Shi W, Gobe GC, McDade L, Mielke LA, Tye H, Masters SL, Belz GT, Huntington ND, Radford-Smith G, Smyth MJ. Souza-Fonseca-Guimaraes F, et al. Cell Death Dis. 2016 Jul 21;7(7):e2302. doi: 10.1038/cddis.2016.215. Cell Death Dis. 2016. PMID: 27441655 Free PMC article.
GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity.
Bunting MD, Varelias A, Souza-Fonseca-Guimaraes F, Schuster IS, Lineburg KE, Kuns RD, Fleming P, Locke KR, Huntington ND, Blazar BR, Lane SW, Tey SK, MacDonald KP, Smyth MJ, Degli-Esposti MA, Hill GR. Bunting MD, et al. Blood. 2017 Feb 2;129(5):630-642. doi: 10.1182/blood-2016-08-734020. Epub 2016 Dec 7. Blood. 2017. PMID: 27927647 Free PMC article.
Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival.
Viant C, Guia S, Hennessy RJ, Rautela J, Pham K, Bernat C, Goh W, Jiao Y, Delconte R, Roger M, Simon V, Souza-Fonseca-Guimaraes F, Grabow S, Belz GT, Kile BT, Strasser A, Gray D, Hodgkin PD, Beutler B, Vivier E, Ugolini S, Huntington ND. Viant C, et al. J Exp Med. 2017 Feb;214(2):491-510. doi: 10.1084/jem.20160869. Epub 2017 Jan 5. J Exp Med. 2017. PMID: 28057804 Free PMC article.
NK cell heparanase controls tumor invasion and immune surveillance.
Putz EM, Mayfosh AJ, Kos K, Barkauskas DS, Nakamura K, Town L, Goodall KJ, Yee DY, Poon IK, Baschuk N, Souza-Fonseca-Guimaraes F, Hulett MD, Smyth MJ. Putz EM, et al. J Clin Invest. 2017 Jun 30;127(7):2777-2788. doi: 10.1172/JCI92958. Epub 2017 Jun 5. J Clin Invest. 2017. Retraction in: J Clin Invest. 2024 Jul 1;134(13):e183295. doi: 10.1172/JCI183295 PMID: 28581441 Free PMC article. Retracted.
94 results