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New N-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity.
Cotman AE, Fulgheri F, Piga M, Peršolja P, Tiz DB, Skok Ž, Durcik M, Sterle M, Dernovšek J, Cruz CD, Tammela P, Szili PÉ, Daruka L, Pál C, Zega A, Mašič LP, Ilaš J, Tomašič T, Kikelj D, Zidar N. Cotman AE, et al. Among authors: zega a. RSC Adv. 2024 Sep 6;14(39):28423-28454. doi: 10.1039/d4ra04802d. eCollection 2024 Sep 4. RSC Adv. 2024. PMID: 39247510 Free PMC article.
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains.
Zidar N, Onali A, Peršolja P, Benedetto Tiz D, Dernovšek J, Skok Ž, Durcik M, Cotman AE, Hrast Rambaher M, Cruz CD, Tammela P, Senerovic L, Jovanovic M, Szili PÉ, Czikkely MS, Pál C, Zega A, Peterlin Mašič L, Ilaš J, Tomašič T, Kikelj D. Zidar N, et al. Among authors: zega a. Eur J Med Chem. 2024 Nov 15;278:116823. doi: 10.1016/j.ejmech.2024.116823. Epub 2024 Sep 1. Eur J Med Chem. 2024. PMID: 39236496 Free article.
Development of narrow-spectrum topoisomerase-targeting antibacterials against mycobacteria.
Sterle M, Habjan E, Piga M, Peršolja P, Durcik M, Dernovšek J, Szili P, Czikkely MS, Zidar N, Janez I, Pal C, Accetto T, Pardo LA, Kikelj D, Peterlin Mašič L, Tomašič T, Bitter W, Cotman AE, Speer A, Zega A. Sterle M, et al. Among authors: zega a. Eur J Med Chem. 2024 Oct 5;276:116693. doi: 10.1016/j.ejmech.2024.116693. Epub 2024 Jul 19. Eur J Med Chem. 2024. PMID: 39053193
Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor: A medicinal chemistry and QTAIM study.
Zidar N, Emanuel Cotman A, Sinnige W, Benek O, Barančokova M, Zega A, Peterlin Mašič L, Tomašič T, Ilaš J, Henderson SR, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Jan Sterk G, Tosso R, Gutierrez L, Enriz RD, Kikelj D. Zidar N, et al. Among authors: zega a. Bioorg Med Chem. 2024 Jul 15;109:117798. doi: 10.1016/j.bmc.2024.117798. Epub 2024 Jun 13. Bioorg Med Chem. 2024. PMID: 38906068 Free article.
Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens.
Sterle M, Durcik M, Stevenson CEM, Henderson SR, Szili PE, Czikkely M, Lawson DM, Maxwell A, Cahard D, Kikelj D, Zidar N, Pal C, Mašič LP, Ilaš J, Tomašič T, Cotman AE, Zega A. Sterle M, et al. Among authors: zega a. ACS Omega. 2023 Jun 28;8(27):24387-24395. doi: 10.1021/acsomega.3c01930. eCollection 2023 Jul 11. ACS Omega. 2023. PMID: 37457471 Free PMC article.
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
Durcik M, Cotman AE, Toplak Ž, Možina Š, Skok Ž, Szili PE, Czikkely M, Maharramov E, Vu TH, Piras MV, Zidar N, Ilaš J, Zega A, Trontelj J, Pardo LA, Hughes D, Huseby D, Berruga-Fernández T, Cao S, Simoff I, Svensson R, Korol SV, Jin Z, Vicente F, Ramos MC, Mundy JEA, Maxwell A, Stevenson CEM, Lawson DM, Glinghammar B, Sjöström E, Bohlin M, Oreskär J, Alvér S, Janssen GV, Sterk GJ, Kikelj D, Pal C, Tomašič T, Peterlin Mašič L. Durcik M, et al. Among authors: zega a. J Med Chem. 2023 Mar 23;66(6):3968-3994. doi: 10.1021/acs.jmedchem.2c01905. Epub 2023 Mar 6. J Med Chem. 2023. PMID: 36877255 Free PMC article.
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.
Skok Ž, Durcik M, Zajec Ž, Gramec Skledar D, Bozovičar K, Pišlar A, Tomašič T, Zega A, Peterlin Mašič L, Kikelj D, Zidar N, Ilaš J. Skok Ž, et al. Among authors: zega a. Eur J Med Chem. 2023 Mar 5;249:115116. doi: 10.1016/j.ejmech.2023.115116. Epub 2023 Jan 18. Eur J Med Chem. 2023. PMID: 36689894 Free article.
69 results