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A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients.
Cassotta A, Mikol V, Bertrand T, Pouzieux S, Le Parc J, Ferrari P, Dumas J, Auer M, Deisenhammer F, Gastaldi M, Franciotta D, Silacci-Fregni C, Fernandez Rodriguez B, Giacchetto-Sasselli I, Foglierini M, Jarrossay D, Geiger R, Sallusto F, Lanzavecchia A, Piccoli L. Cassotta A, et al. Among authors: piccoli l. Nat Med. 2019 Sep;25(9):1402-1407. doi: 10.1038/s41591-019-0568-2. Epub 2019 Sep 9. Nat Med. 2019. PMID: 31501610 Free PMC article.
First Measurement of Electron Neutrino Appearance in NOvA.
Adamson P, Ader C, Andrews M, Anfimov N, Anghel I, Arms K, Arrieta-Diaz E, Aurisano A, Ayres DS, Backhouse C, Baird M, Bambah BA, Bays K, Bernstein R, Betancourt M, Bhatnagar V, Bhuyan B, Bian J, Biery K, Blackburn T, Bocean V, Bogert D, Bolshakova A, Bowden M, Bower C, Broemmelsiek D, Bromberg C, Brunetti G, Bu X, Butkevich A, Capista D, Catano-Mur E, Chase TR, Childress S, Choudhary BC, Chowdhury B, Coan TE, Coelho JA, Colo M, Cooper J, Corwin L, Cronin-Hennessy D, Cunningham A, Davies GS, Davies JP, Del Tutto M, Derwent PF, Deepthi KN, Demuth D, Desai S, Deuerling G, Devan A, Dey J, Dharmapalan R, Ding P, Dixon S, Djurcic Z, Dukes EC, Duyang H, Ehrlich R, Feldman GJ, Felt N, Fenyves EJ, Flumerfelt E, Foulkes S, Frank MJ, Freeman W, Gabrielyan M, Gallagher HR, Gebhard M, Ghosh T, Gilbert W, Giri A, Goadhouse S, Gomes RA, Goodenough L, Goodman MC, Grichine V, Grossman N, Group R, Grudzinski J, Guarino V, Guo B, Habig A, Handler T, Hartnell J, Hatcher R, Hatzikoutelis A, Heller K, Howcroft C, Huang J, Huang X, Hylen J, Ishitsuka M, Jediny F, Jensen C, Jensen D, Johnson C, Jostlein H, Kafka GK, Kamyshkov Y, Kasahara SM, Kasetti S, Kephart K, Koizumi G, Kotelnikov S, Kourbanis I, Kr… See abstract for full author list ➔ Adamson P, et al. Among authors: piccoli l. Phys Rev Lett. 2016 Apr 15;116(15):151806. doi: 10.1103/PhysRevLett.116.151806. Epub 2016 Apr 13. Phys Rev Lett. 2016. PMID: 27127961
Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Pappas L, Foglierini M, Piccoli L, Kallewaard NL, Turrini F, Silacci C, Fernandez-Rodriguez B, Agatic G, Giacchetto-Sasselli I, Pellicciotta G, Sallusto F, Zhu Q, Vicenzi E, Corti D, Lanzavecchia A. Pappas L, et al. Among authors: piccoli l. Nature. 2014 Dec 18;516(7531):418-22. doi: 10.1038/nature13764. Epub 2014 Oct 5. Nature. 2014. PMID: 25296253
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan J, Pieper K, Piccoli L, Abdi A, Perez MF, Geiger R, Tully CM, Jarrossay D, Maina Ndungu F, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A. Tan J, et al. Among authors: piccoli l. Nature. 2016 Jan 7;529(7584):105-109. doi: 10.1038/nature16450. Epub 2015 Dec 23. Nature. 2016. PMID: 26700814 Free PMC article.
High-avidity IgA protects the intestine by enchaining growing bacteria.
Moor K, Diard M, Sellin ME, Felmy B, Wotzka SY, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co AD, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regoes RR, Loverdo C, Stocker R, Brumley DR, Hardt WD, Slack E. Moor K, et al. Among authors: piccoli l. Nature. 2017 Apr 27;544(7651):498-502. doi: 10.1038/nature22058. Epub 2017 Apr 12. Nature. 2017. PMID: 28405025
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper K, Tan J, Piccoli L, Foglierini M, Barbieri S, Chen Y, Silacci-Fregni C, Wolf T, Jarrossay D, Anderle M, Abdi A, Ndungu FM, Doumbo OK, Traore B, Tran TM, Jongo S, Zenklusen I, Crompton PD, Daubenberger C, Bull PC, Sallusto F, Lanzavecchia A. Pieper K, et al. Among authors: piccoli l. Nature. 2017 Aug 31;548(7669):597-601. doi: 10.1038/nature23670. Epub 2017 Aug 23. Nature. 2017. PMID: 28847005 Free PMC article.
Variable domain N-linked glycosylation and negative surface charge are key features of monoclonal ACPA: Implications for B-cell selection.
Lloyd KA, Steen J, Amara K, Titcombe PJ, Israelsson L, Lundström SL, Zhou D, Zubarev RA, Reed E, Piccoli L, Gabay C, Lanzavecchia A, Baeten D, Lundberg K, Mueller DL, Klareskog L, Malmström V, Grönwall C. Lloyd KA, et al. Among authors: piccoli l. Eur J Immunol. 2018 Jun;48(6):1030-1045. doi: 10.1002/eji.201747446. Epub 2018 Apr 6. Eur J Immunol. 2018. PMID: 29512823 Free article.
A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein.
Tan J, Sack BK, Oyen D, Zenklusen I, Piccoli L, Barbieri S, Foglierini M, Fregni CS, Marcandalli J, Jongo S, Abdulla S, Perez L, Corradin G, Varani L, Sallusto F, Sim BKL, Hoffman SL, Kappe SHI, Daubenberger C, Wilson IA, Lanzavecchia A. Tan J, et al. Among authors: piccoli l. Nat Med. 2018 May;24(4):401-407. doi: 10.1038/nm.4513. Epub 2018 Mar 19. Nat Med. 2018. PMID: 29554084 Free PMC article.
125 results