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A Scaffold-Diversity Synthesis of Biologically Intriguing Cyclic Sulfonamides.
Zimmermann S, Akbarzadeh M, Otte F, Strohmann C, Sankar MG, Ziegler S, Pahl A, Sievers S, Kumar K. Zimmermann S, et al. Among authors: akbarzadeh m. Chemistry. 2019 Dec 5;25(68):15498-15503. doi: 10.1002/chem.201904175. Epub 2019 Nov 7. Chemistry. 2019. PMID: 31518018 Free PMC article.
Discovery of Covalent Inhibitors Targeting the Transcriptional Enhanced Associate Domain Central Pocket.
Karatas H, Akbarzadeh M, Adihou H, Hahne G, Pobbati AV, Yihui Ng E, Guéret SM, Sievers S, Pahl A, Metz M, Zinken S, Dötsch L, Nowak C, Thavam S, Friese A, Kang C, Hong W, Waldmann H. Karatas H, et al. Among authors: akbarzadeh m. J Med Chem. 2020 Oct 22;63(20):11972-11989. doi: 10.1021/acs.jmedchem.0c01275. Epub 2020 Oct 1. J Med Chem. 2020. PMID: 32907324 Free PMC article.
The Pseudo-Natural Product Rhonin Targets RHOGDI.
Akbarzadeh M, Flegel J, Patil S, Shang E, Narayan R, Buchholzer M, Kazemein Jasemi NS, Grigalunas M, Krzyzanowski A, Abegg D, Shuster A, Potowski M, Karatas H, Karageorgis G, Mosaddeghzadeh N, Zischinsky ML, Merten C, Golz C, Brieger L, Strohmann C, Antonchick AP, Janning P, Adibekian A, Goody RS, Ahmadian MR, Ziegler S, Waldmann H. Akbarzadeh M, et al. Angew Chem Int Ed Engl. 2022 Apr 25;61(18):e202115193. doi: 10.1002/anie.202115193. Epub 2022 Mar 2. Angew Chem Int Ed Engl. 2022. PMID: 35170181 Free PMC article.
Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.
Hart P', Hommen P, Noisier A, Krzyzanowski A, Schüler D, Porfetye AT, Akbarzadeh M, Vetter IR, Adihou H, Waldmann H. Hart P', et al. Among authors: akbarzadeh m. Angew Chem Int Ed Engl. 2021 Jan 25;60(4):1813-1820. doi: 10.1002/anie.202009749. Epub 2020 Nov 24. Angew Chem Int Ed Engl. 2021. PMID: 33022847 Free PMC article.
TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics.
Kunig VBK, Potowski M, Akbarzadeh M, Klika Škopić M, Dos Santos Smith D, Arendt L, Dormuth I, Adihou H, Andlovic B, Karatas H, Shaabani S, Zarganes-Tzitzikas T, Neochoritis CG, Zhang R, Groves M, Guéret SM, Ottmann C, Rahnenführer J, Fried R, Dömling A, Brunschweiger A. Kunig VBK, et al. Among authors: akbarzadeh m. Angew Chem Int Ed Engl. 2020 Nov 9;59(46):20338-20342. doi: 10.1002/anie.202006280. Epub 2020 Jul 15. Angew Chem Int Ed Engl. 2020. PMID: 32537835 Free PMC article.
Structural snapshots of RAF kinase interactions.
Rezaei Adariani S, Buchholzer M, Akbarzadeh M, Nakhaei-Rad S, Dvorsky R, Ahmadian MR. Rezaei Adariani S, et al. Among authors: akbarzadeh m. Biochem Soc Trans. 2018 Dec 17;46(6):1393-1406. doi: 10.1042/BST20170528. Epub 2018 Oct 31. Biochem Soc Trans. 2018. PMID: 30381334 Review.
Inhibition of the RacGEF VAV3 by the small molecule IODVA1 impedes RAC signaling and overcomes resistance to tyrosine kinase inhibition in acute lymphoblastic leukemia.
Hegde S, Gasilina A, Wunderlich M, Lin Y, Buchholzer M, Krumbach OHF, Akbarzadeh M, Ahmadian MR, Seibel W, Zheng Y, Perentesis JP, Mizukawa BE, Vinnedge LP, Cancelas JA, Nassar NN. Hegde S, et al. Among authors: akbarzadeh m. Leukemia. 2022 Mar;36(3):637-647. doi: 10.1038/s41375-021-01455-3. Epub 2021 Oct 28. Leukemia. 2022. PMID: 34711926 Free PMC article.
A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function.
Lam MT, Coppola S, Krumbach OHF, Prencipe G, Insalaco A, Cifaldi C, Brigida I, Zara E, Scala S, Di Cesare S, Martinelli S, Di Rocco M, Pascarella A, Niceta M, Pantaleoni F, Ciolfi A, Netter P, Carisey AF, Diehl M, Akbarzadeh M, Conti F, Merli P, Pastore A, Levi Mortera S, Camerini S, Farina L, Buchholzer M, Pannone L, Cao TN, Coban-Akdemir ZH, Jhangiani SN, Muzny DM, Gibbs RA, Basso-Ricci L, Chiriaco M, Dvorsky R, Putignani L, Carsetti R, Janning P, Stray-Pedersen A, Erichsen HC, Horne A, Bryceson YT, Torralba-Raga L, Ramme K, Rosti V, Bracaglia C, Messia V, Palma P, Finocchi A, Locatelli F, Chinn IK, Lupski JR, Mace EM, Cancrini C, Aiuti A, Ahmadian MR, Orange JS, De Benedetti F, Tartaglia M. Lam MT, et al. Among authors: akbarzadeh m. J Exp Med. 2019 Dec 2;216(12):2778-2799. doi: 10.1084/jem.20190147. Epub 2019 Oct 10. J Exp Med. 2019. PMID: 31601675 Free PMC article.
301 results