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The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Rudolf AF, et al. Among authors: bishop b. Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548691 Free PMC article.
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.
Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C. Griffiths SC, et al. Among authors: bishop b. Nat Commun. 2021 Dec 9;12(1):7171. doi: 10.1038/s41467-021-27475-2. Nat Commun. 2021. PMID: 34887403 Free PMC article.
Glypicans shield the Wnt lipid moiety to enable signalling at a distance.
McGough IJ, Vecchia L, Bishop B, Malinauskas T, Beckett K, Joshi D, O'Reilly N, Siebold C, Jones EY, Vincent JP. McGough IJ, et al. Among authors: bishop b. Nature. 2020 Sep;585(7823):85-90. doi: 10.1038/s41586-020-2498-z. Epub 2020 Jul 22. Nature. 2020. PMID: 32699409 Free PMC article.
Automation of large scale transient protein expression in mammalian cells.
Zhao Y, Bishop B, Clay JE, Lu W, Jones M, Daenke S, Siebold C, Stuart DI, Jones EY, Aricescu AR. Zhao Y, et al. Among authors: bishop b. J Struct Biol. 2011 Aug;175(2):209-15. doi: 10.1016/j.jsb.2011.04.017. Epub 2011 May 6. J Struct Biol. 2011. PMID: 21571074 Free PMC article.
Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling.
Robinson RA, Griffiths SC, van de Haar LL, Malinauskas T, van Battum EY, Zelina P, Schwab RA, Karia D, Malinauskaite L, Brignani S, van den Munkhof MH, Düdükcü Ö, De Ruiter AA, Van den Heuvel DMA, Bishop B, Elegheert J, Aricescu AR, Pasterkamp RJ, Siebold C. Robinson RA, et al. Among authors: bishop b. Cell. 2021 Apr 15;184(8):2103-2120.e31. doi: 10.1016/j.cell.2021.02.045. Epub 2021 Mar 18. Cell. 2021. PMID: 33740419 Free PMC article.
461 results