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The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Rudolf AF, et al. Among authors: el omari k. Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548691 Free PMC article.
Characterization and engineering of a plastic-degrading aromatic polyesterase.
Austin HP, Allen MD, Donohoe BS, Rorrer NA, Kearns FL, Silveira RL, Pollard BC, Dominick G, Duman R, El Omari K, Mykhaylyk V, Wagner A, Michener WE, Amore A, Skaf MS, Crowley MF, Thorne AW, Johnson CW, Woodcock HL, McGeehan JE, Beckham GT. Austin HP, et al. Among authors: el omari k. Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4350-E4357. doi: 10.1073/pnas.1718804115. Epub 2018 Apr 17. Proc Natl Acad Sci U S A. 2018. PMID: 29666242 Free PMC article.
Anomalous X-ray diffraction studies of ion transport in K+ channels.
Langan PS, Vandavasi VG, Weiss KL, Afonine PV, El Omari K, Duman R, Wagner A, Coates L. Langan PS, et al. Among authors: el omari k. Nat Commun. 2018 Oct 31;9(1):4540. doi: 10.1038/s41467-018-06957-w. Nat Commun. 2018. PMID: 30382100 Free PMC article.
Identifying dynamic, partially occupied residues using anomalous scattering.
Rocchio S, Duman R, El Omari K, Mykhaylyk V, Orr C, Yan Z, Salmon L, Wagner A, Bardwell JCA, Horowitz S. Rocchio S, et al. Among authors: el omari k. Acta Crystallogr D Struct Biol. 2019 Dec 1;75(Pt 12):1084-1095. doi: 10.1107/S2059798319014475. Epub 2019 Nov 19. Acta Crystallogr D Struct Biol. 2019. PMID: 31793902 Free PMC article.
92 results