Kinnebrew M - Search Results

1

The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.

Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, Rohatgi R, Siebold C. Rudolf AF, et al. Among authors: kinnebrew m. Nat Chem Biol. 2019 Oct;15(10):975-982. doi: 10.1038/s41589-019-0370-y. Epub 2019 Sep 23. Nat Chem Biol. 2019. PMID: 31548691 Free PMC article.

2

CRISPR Screens Uncover Genes that Regulate Target Cell Sensitivity to the Morphogen Sonic Hedgehog.

Pusapati GV, Kong JH, Patel BB, Krishnan A, Sagner A, Kinnebrew M, Briscoe J, Aravind L, Rohatgi R. Pusapati GV, et al. Among authors: kinnebrew m. Dev Cell. 2018 Jan 8;44(1):113-129.e8. doi: 10.1016/j.devcel.2017.12.003. Epub 2017 Dec 28. Dev Cell. 2018. PMID: 29290584 Free PMC article.

3

Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling.

Kowatsch C, Woolley RE, Kinnebrew M, Rohatgi R, Siebold C. Kowatsch C, et al. Among authors: kinnebrew m. Curr Opin Struct Biol. 2019 Aug;57:204-214. doi: 10.1016/j.sbi.2019.05.015. Epub 2019 Jun 24. Curr Opin Struct Biol. 2019. PMID: 31247512 Free PMC article. Review.

4

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Kinnebrew M, et al. Elife. 2019 Oct 30;8:e50051. doi: 10.7554/eLife.50051. Elife. 2019. PMID: 31657721 Free PMC article.

5

Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution.

Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB. Gokhman D, et al. Among authors: kinnebrew m. Nat Genet. 2021 Apr;53(4):467-476. doi: 10.1038/s41588-021-00804-3. Epub 2021 Mar 17. Nat Genet. 2021. PMID: 33731941 Free PMC article.

6

Publisher Correction: Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution.

Gokhman D, Agoglia RM, Kinnebrew M, Gordon W, Sun D, Bajpai VK, Naqvi S, Chen C, Chan A, Chen C, Petrov DA, Ahituv N, Zhang H, Mishina Y, Wysocka J, Rohatgi R, Fraser HB. Gokhman D, et al. Among authors: kinnebrew m. Nat Genet. 2021 Apr;53(4):587. doi: 10.1038/s41588-021-00849-4. Nat Genet. 2021. PMID: 33762754 No abstract available.

7

Measuring and Manipulating Membrane Cholesterol for the Study of Hedgehog Signaling.

Kinnebrew M, Johnson KA, Radhakrishnan A, Rohatgi R. Kinnebrew M, et al. Methods Mol Biol. 2022;2374:73-87. doi: 10.1007/978-1-0716-1701-4_7. Methods Mol Biol. 2022. PMID: 34562244 Free PMC article.

8

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.

Kinnebrew M, Luchetti G, Sircar R, Frigui S, Viti LV, Naito T, Beckert F, Saheki Y, Siebold C, Radhakrishnan A, Rohatgi R. Kinnebrew M, et al. Elife. 2021 Oct 26;10:e70504. doi: 10.7554/eLife.70504. Elife. 2021. PMID: 34698632 Free PMC article.

9

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.

Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Kinnebrew M, et al. Sci Adv. 2022 Jun 3;8(22):eabm5563. doi: 10.1126/sciadv.abm5563. Epub 2022 Jun 3. Sci Adv. 2022. PMID: 35658032 Free PMC article.

10

The Energetics and Ion Coupling of Cholesterol Transport Through Patched1.

Ansell TB, Corey RA, Viti LV, Kinnebrew M, Rohatgi R, Siebold C, Sansom MSP. Ansell TB, et al. Among authors: kinnebrew m. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528445. doi: 10.1101/2023.02.14.528445. bioRxiv. 2023. Update in: Sci Adv. 2023 Aug 25;9(34):eadh1609. doi: 10.1126/sciadv.adh1609 PMID: 36824746 Free PMC article. Updated. Preprint.

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