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The Trypanosoma brucei-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells.
Fitzgerald HK, O'Rourke SA, Desmond E, Neto NGB, Monaghan MG, Tosetto M, Doherty J, Ryan EJ, Doherty GA, Nolan DP, Fletcher JM, Dunne A. Fitzgerald HK, et al. Among authors: nolan dp. Antioxidants (Basel). 2022 Jan 15;11(1):164. doi: 10.3390/antiox11010164. Antioxidants (Basel). 2022. PMID: 35052669 Free PMC article.
Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion.
McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP. McGettrick AF, et al. Among authors: nolan dp. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7778-E7787. doi: 10.1073/pnas.1608221113. Epub 2016 Nov 15. Proc Natl Acad Sci U S A. 2016. PMID: 27856732 Free PMC article.
The Trypanosoma Brucei KIFC1 Kinesin Ensures the Fast Antibody Clearance Required for Parasite Infectivity.
Lecordier L, Uzureau S, Vanwalleghem G, Deleu M, Crowet JM, Barry P, Moran B, Voorheis P, Dumitru AC, Yamaryo-Botté Y, Dieu M, Tebabi P, Vanhollebeke B, Lins L, Botté CY, Alsteens D, Dufrêne Y, Pérez-Morga D, Nolan DP, Pays E. Lecordier L, et al. Among authors: nolan dp. iScience. 2020 Aug 20;23(9):101476. doi: 10.1016/j.isci.2020.101476. eCollection 2020 Sep 25. iScience. 2020. PMID: 32889430 Free PMC article.
55 results