Southworth DR - Search Results

1

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation.

Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Chen JJ, et al. Among authors: southworth dr. J Biol Chem. 2019 Dec 13;294(50):18952-18966. doi: 10.1074/jbc.RA119.009432. Epub 2019 Oct 2. J Biol Chem. 2019. PMID: 31578281 Free PMC article.

2

The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.

Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. Connarn JN, et al. Among authors: southworth dr. J Biol Chem. 2014 Jan 31;289(5):2908-17. doi: 10.1074/jbc.M113.519421. Epub 2013 Dec 10. J Biol Chem. 2014. PMID: 24327656 Free PMC article.

3

Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

Assimon VA, Southworth DR, Gestwicki JE. Assimon VA, et al. Among authors: southworth dr. Biochemistry. 2015 Dec 8;54(48):7120-31. doi: 10.1021/acs.biochem.5b00801. Epub 2015 Nov 25. Biochemistry. 2015. PMID: 26565746 Free PMC article.

4

BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins.

Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. Rauch JN, et al. Among authors: southworth dr. J Mol Biol. 2017 Jan 6;429(1):128-141. doi: 10.1016/j.jmb.2016.11.013. Epub 2016 Nov 21. J Mol Biol. 2017. PMID: 27884606 Free PMC article.

5

Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing.

Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ. Read DF, et al. Among authors: southworth dr. FEBS Lett. 2017 Jun;591(11):1601-1610. doi: 10.1002/1873-3468.12627. Epub 2017 May 22. FEBS Lett. 2017. PMID: 28303570 Free PMC article.

6

X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.

Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. Cesa LC, et al. Among authors: southworth dr. J Biol Chem. 2018 Feb 16;293(7):2370-2380. doi: 10.1074/jbc.RA117.000634. Epub 2017 Dec 18. J Biol Chem. 2018. PMID: 29255093 Free PMC article.

7

Polyphosphate Stabilizes Protein Unfolding Intermediates as Soluble Amyloid-like Oligomers.

Yoo NG, Dogra S, Meinen BA, Tse E, Haefliger J, Southworth DR, Gray MJ, Dahl JU, Jakob U. Yoo NG, et al. Among authors: southworth dr. J Mol Biol. 2018 Oct 19;430(21):4195-4208. doi: 10.1016/j.jmb.2018.08.016. Epub 2018 Aug 18. J Mol Biol. 2018. PMID: 30130556 Free PMC article.

8

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.

Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Freilich R, et al. Among authors: southworth dr. Nat Commun. 2018 Nov 1;9(1):4563. doi: 10.1038/s41467-018-07012-4. Nat Commun. 2018. PMID: 30385828 Free PMC article.

9

Chaperone activation and client binding of a 2-cysteine peroxiredoxin.

Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U. Teixeira F, et al. Among authors: southworth dr. Nat Commun. 2019 Feb 8;10(1):659. doi: 10.1038/s41467-019-08565-8. Nat Commun. 2019. PMID: 30737390 Free PMC article.

10

Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase.

Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR. Rizo AN, et al. Among authors: southworth dr. Nat Commun. 2019 Jun 3;10(1):2393. doi: 10.1038/s41467-019-10150-y. Nat Commun. 2019. PMID: 31160557 Free PMC article.

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