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Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23.
Yablonska S, Ganesan V, Ferrando LM, Kim J, Pyzel A, Baranova OV, Khattar NK, Larkin TM, Baranov SV, Chen N, Strohlein CE, Stevens DA, Wang X, Chang YF, Schurdak ME, Carlisle DL, Minden JS, Friedlander RM. Yablonska S, et al. Among authors: friedlander rm. Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16593-16602. doi: 10.1073/pnas.1904101116. Epub 2019 Jul 25. Proc Natl Acad Sci U S A. 2019. PMID: 31346086 Free PMC article.
Moving toward a gene therapy for Huntington's disease.
Glorioso JC, Cohen JB, Carlisle DL, Munoz-Sanjuan I, Friedlander RM. Glorioso JC, et al. Among authors: friedlander rm. Gene Ther. 2015 Dec;22(12):931-3. doi: 10.1038/gt.2015.102. Gene Ther. 2015. PMID: 26633828 No abstract available.
Inhibition of mitochondrial protein import by mutant huntingtin.
Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S, Carlisle DL, Ferrante RJ, Kim AH, Friedlander RM. Yano H, et al. Among authors: friedlander rm. Nat Neurosci. 2014 Jun;17(6):822-31. doi: 10.1038/nn.3721. Epub 2014 May 18. Nat Neurosci. 2014. PMID: 24836077 Free PMC article.
Mitochondria modulate programmed neuritic retraction.
Baranov SV, Baranova OV, Yablonska S, Suofu Y, Vazquez AL, Kozai TDY, Cui XT, Ferrando LM, Larkin TM, Tyurina YY, Kagan VE, Carlisle DL, Kristal BS, Friedlander RM. Baranov SV, et al. Among authors: friedlander rm. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):650-659. doi: 10.1073/pnas.1811021116. Epub 2018 Dec 24. Proc Natl Acad Sci U S A. 2019. PMID: 30584104 Free PMC article.
245 results