Fishwick CWG - Search Results

1

Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.

Cain R, Salimraj R, Punekar AS, Bellini D, Fishwick CWG, Czaplewski L, Scott DJ, Harris G, Dowson CG, Lloyd AJ, Roper DI. Cain R, et al. Among authors: fishwick cwg. J Med Chem. 2019 Nov 14;62(21):9703-9717. doi: 10.1021/acs.jmedchem.9b01131. Epub 2019 Nov 5. J Med Chem. 2019. PMID: 31626547 Free article.

2

From TgO/GABA-AT, GABA, and T-263 Mutant to Conception of Toxoplasma.

Lykins J, Moschitto MJ, Zhou Y, Filippova EV, Le HV, Tomita T, Fox BA, Bzik DJ, Su C, Rajagopala SV, Flores K, Spano F, Woods S, Roberts CW, Hua C, El Bissati K, Wheeler KM, Dovgin S, Muench SP, McPhillie M, Fishwick CWG, Anderson WF, Lee PJ, Hickman M, Weiss LM, Dubey JP, Lorenzi HA, Silverman RB, McLeod RL. Lykins J, et al. Among authors: fishwick cwg. iScience. 2023 Nov 16;27(1):108477. doi: 10.1016/j.isci.2023.108477. eCollection 2024 Jan 19. iScience. 2023. PMID: 38205261 Free PMC article.

3

Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

Horton JR, Bostock JM, Chopra I, Hesse L, Phillips SE, Adams DJ, Johnson AP, Fishwick CW. Horton JR, et al. Bioorg Med Chem Lett. 2003 May 5;13(9):1557-60. doi: 10.1016/s0960-894x(03)00176-8. Bioorg Med Chem Lett. 2003. PMID: 12699754

4

The first de novo-designed antagonists of the human NK(2) receptor.

Ali MA, Bhogal N, Findlay JB, Fishwick CW. Ali MA, et al. J Med Chem. 2005 Sep 8;48(18):5655-8. doi: 10.1021/jm050533o. J Med Chem. 2005. PMID: 16134933

5

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli.

Besong GE, Bostock JM, Stubbings W, Chopra I, Roper DI, Lloyd AJ, Fishwick CW, Johnson AP. Besong GE, et al. Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6403-6. doi: 10.1002/anie.200501662. Angew Chem Int Ed Engl. 2005. PMID: 16158456 No abstract available.

6

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Heikkilä T, Thirumalairajan S, Davies M, Parsons MR, McConkey AG, Fishwick CW, Johnson AP. Heikkilä T, et al. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. doi: 10.1016/j.bmcl.2005.09.045. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236496

7

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

Heikkilä T, Ramsey C, Davies M, Galtier C, Stead AM, Johnson AP, Fishwick CW, Boa AN, McConkey GA. Heikkilä T, et al. J Med Chem. 2007 Jan 25;50(2):186-91. doi: 10.1021/jm060687j. J Med Chem. 2007. PMID: 17228860

8

2-Aminotetralones: novel inhibitors of MurA and MurZ.

Dunsmore CJ, Miller K, Blake KL, Patching SG, Henderson PJ, Garnett JA, Stubbings WJ, Phillips SE, Palestrant DJ, Angeles Jde L, Leeds JA, Chopra I, Fishwick CW. Dunsmore CJ, et al. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1730-4. doi: 10.1016/j.bmcl.2008.01.089. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18261901

9

Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB).

Sova M, Cadez G, Turk S, Majce V, Polanc S, Batson S, Lloyd AJ, Roper DI, Fishwick CW, Gobec S. Sova M, et al. Bioorg Med Chem Lett. 2009 Mar 1;19(5):1376-9. doi: 10.1016/j.bmcl.2009.01.034. Epub 2009 Jan 19. Bioorg Med Chem Lett. 2009. PMID: 19196510

10

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP. Davies M, et al. J Med Chem. 2009 May 14;52(9):2683-93. doi: 10.1021/jm800963t. J Med Chem. 2009. PMID: 19351152

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