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Reproducing human and cross-species drug toxicities using a Liver-Chip.
Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA. Jang KJ, et al. Among authors: williams d. Sci Transl Med. 2019 Nov 6;11(517):eaax5516. doi: 10.1126/scitranslmed.aax5516. Sci Transl Med. 2019. PMID: 31694927
Role of reactive metabolites in drug-induced hepatotoxicity.
Srivastava A, Maggs JL, Antoine DJ, Williams DP, Smith DA, Park BK. Srivastava A, et al. Among authors: williams dp. Handb Exp Pharmacol. 2010;(196):165-94. doi: 10.1007/978-3-642-00663-0_7. Handb Exp Pharmacol. 2010. PMID: 20020263 Review.
Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery.
Ewart L, Dehne EM, Fabre K, Gibbs S, Hickman J, Hornberg E, Ingelman-Sundberg M, Jang KJ, Jones DR, Lauschke VM, Marx U, Mettetal JT, Pointon A, Williams D, Zimmermann WH, Newham P. Ewart L, et al. Among authors: williams d. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:65-82. doi: 10.1146/annurev-pharmtox-010617-052722. Epub 2017 Oct 13. Annu Rev Pharmacol Toxicol. 2018. PMID: 29029591 Review.
Introducing an automated high content confocal imaging approach for Organs-on-Chips.
Peel S, Corrigan AM, Ehrhardt B, Jang KJ, Caetano-Pinto P, Boeckeler M, Rubins JE, Kodella K, Petropolis DB, Ronxhi J, Kulkarni G, Foster AJ, Williams D, Hamilton GA, Ewart L. Peel S, et al. Among authors: williams d. Lab Chip. 2019 Jan 29;19(3):410-421. doi: 10.1039/c8lc00829a. Lab Chip. 2019. PMID: 30663729
Integrated in vitro models for hepatic safety and metabolism: evaluation of a human Liver-Chip and liver spheroid.
Foster AJ, Chouhan B, Regan SL, Rollison H, Amberntsson S, Andersson LC, Srivastava A, Darnell M, Cairns J, Lazic SE, Jang KJ, Petropolis DB, Kodella K, Rubins JE, Williams D, Hamilton GA, Ewart L, Morgan P. Foster AJ, et al. Among authors: williams d. Arch Toxicol. 2019 Apr;93(4):1021-1037. doi: 10.1007/s00204-019-02427-4. Epub 2019 Mar 26. Arch Toxicol. 2019. PMID: 30915487
On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.
McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L. McAleer CW, et al. Among authors: williams d. Sci Rep. 2019 Jul 3;9(1):9619. doi: 10.1038/s41598-019-45656-4. Sci Rep. 2019. PMID: 31270362 Free PMC article.
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