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LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune proinflammatory phenotypes.
Noor S, Sun MS, Vanderwall AG, Havard MA, Sanchez JE, Harris NW, Nysus MV, Norenberg JP, West HT, Wagner CR, Jantzie LL, Mellios N, Milligan ED. Noor S, et al. Among authors: vanderwall ag. Neuroimmunol Neuroinflamm. 2019;6:10. doi: 10.20517/2347-8659.2019.18. Epub 2019 Jul 22. Neuroimmunol Neuroinflamm. 2019. PMID: 31763376 Free PMC article.
Prenatal alcohol exposure potentiates chronic neuropathic pain, spinal glial and immune cell activation and alters sciatic nerve and DRG cytokine levels.
Noor S, Sanchez JJ, Vanderwall AG, Sun MS, Maxwell JR, Davies S, Jantzie LL, Petersen TR, Savage DD, Milligan ED. Noor S, et al. Among authors: vanderwall ag. Brain Behav Immun. 2017 Mar;61:80-95. doi: 10.1016/j.bbi.2016.12.016. Epub 2016 Dec 20. Brain Behav Immun. 2017. PMID: 28011263 Free PMC article.
Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues.
Vanderwall AG, Noor S, Sun MS, Sanchez JE, Yang XO, Jantzie LL, Mellios N, Milligan ED. Vanderwall AG, et al. Brain Behav Immun. 2018 Mar;69:91-112. doi: 10.1016/j.bbi.2017.11.004. Epub 2017 Nov 4. Brain Behav Immun. 2018. PMID: 29113923 Free PMC article.
The FDA-approved compound, pramipexole and the clinical-stage investigational drug, dexpramipexole, reverse chronic allodynia from sciatic nerve damage in mice, and alter IL-1β and IL-10 expression from immune cell culture.
Sanchez JE, Noor S, Sun MS, Zimmerly J, Pasmay A, Sanchez JJ, Vanderwall AG, Haynes MK, Sklar LA, Escalona PR, Milligan ED. Sanchez JE, et al. Among authors: vanderwall ag. Neurosci Lett. 2023 Sep 25;814:137419. doi: 10.1016/j.neulet.2023.137419. Epub 2023 Aug 7. Neurosci Lett. 2023. PMID: 37558176 Free PMC article.