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286 results

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Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections.
Liu B, Trout REL, Chu GH, McGarry D, Jackson RW, Hamrick JC, Daigle DM, Cusick SM, Pozzi C, De Luca F, Benvenuti M, Mangani S, Docquier JD, Weiss WJ, Pevear DC, Xerri L, Burns CJ. Liu B, et al. Among authors: jackson rw. J Med Chem. 2020 Mar 26;63(6):2789-2801. doi: 10.1021/acs.jmedchem.9b01518. Epub 2019 Dec 16. J Med Chem. 2020. PMID: 31765155 Free PMC article.
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa.
Hamrick JC, Docquier JD, Uehara T, Myers CL, Six DA, Chatwin CL, John KJ, Vernacchio SF, Cusick SM, Trout REL, Pozzi C, De Luca F, Benvenuti M, Mangani S, Liu B, Jackson RW, Moeck G, Xerri L, Burns CJ, Pevear DC, Daigle DM. Hamrick JC, et al. Among authors: jackson rw. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01963-19. doi: 10.1128/AAC.01963-19. Print 2020 Feb 21. Antimicrob Agents Chemother. 2020. PMID: 31871094 Free PMC article.
Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes.
Trout RE, Zulli A, Mesaros E, Jackson RW, Boyd S, Liu B, Hamrick J, Daigle D, Chatwin CL, John K, McLaughlin L, Cusick SM, Weiss WJ, Pulse ME, Pevear DC, Moeck G, Xerri L, Burns CJ. Trout RE, et al. Among authors: jackson rw. J Med Chem. 2021 Jul 22;64(14):10155-10166. doi: 10.1021/acs.jmedchem.1c00437. Epub 2021 Jun 30. J Med Chem. 2021. PMID: 34191513 Free PMC article.
The discovery of pyrano[3,4-b]indole-based allosteric inhibitors of HCV NS5B polymerase with in vivo activity.
Laporte MG, Jackson RW, Draper TL, Gaboury JA, Galie K, Herbertz T, Hussey AR, Rippin SR, Benetatos CA, Chunduru SK, Christensen JS, Coburn GA, Rizzo CJ, Rhodes G, O'Connell J, Howe AY, Mansour TS, Collett MS, Pevear DC, Young DC, Gao T, Tyrrell DL, Kneteman NM, Burns CJ, Condon SM. Laporte MG, et al. Among authors: jackson rw. ChemMedChem. 2008 Oct;3(10):1508-15. doi: 10.1002/cmdc.200800168. ChemMedChem. 2008. PMID: 18729128 No abstract available.
Benzobicyclooctanes as novel inhibitors of TNF-alpha signaling.
Jackson RW, Gelinas R, Baughman TA, Cox T, Howbert JJ, Kucera KA, Latham JA, Ramsdell F, Singh D, Darwish IS. Jackson RW, et al. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1093-7. doi: 10.1016/s0960-894x(02)00098-7. Bioorg Med Chem Lett. 2002. PMID: 11909725
Pseudomonas fluorescens.
Taylor TB, Silby MW, Jackson RW. Taylor TB, et al. Among authors: jackson rw. Trends Microbiol. 2024 Nov 28:S0966-842X(24)00289-0. doi: 10.1016/j.tim.2024.11.005. Online ahead of print. Trends Microbiol. 2024. PMID: 39613688 Free article. No abstract available.
Coevolutionary analysis of Pseudomonas syringae-phage interactions to help with rational design of phage treatments.
Rabiey M, Grace ER, Pawlos P, Bihi M, Ahmed H, Hampson GE, Al Riyami A, Alharbi L, Sanchez-Lucas R, Korotania N, Ciusa ML, Mosley O, Hulin MT, Baxter L, Dhaouadi S, Vinchira-Villarraga D, Jackson RW. Rabiey M, et al. Among authors: jackson rw. Microb Biotechnol. 2024 Jun;17(6):e14489. doi: 10.1111/1751-7915.14489. Microb Biotechnol. 2024. PMID: 38864499 Free PMC article.
286 results