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Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.
Patro SC, Brandt LD, Bale MJ, Halvas EK, Joseph KW, Shao W, Wu X, Guo S, Murrell B, Wiegand A, Spindler J, Raley C, Hautman C, Sobolewski M, Fennessey CM, Hu WS, Luke B, Hasson JM, Niyongabo A, Capoferri AA, Keele BF, Milush J, Hoh R, Deeks SG, Maldarelli F, Hughes SH, Coffin JM, Rausch JW, Mellors JW, Kearney MF. Patro SC, et al. Among authors: wiegand a. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25891-25899. doi: 10.1073/pnas.1910334116. Epub 2019 Nov 27. Proc Natl Acad Sci U S A. 2019. PMID: 31776247 Free PMC article.
No evidence of HIV replication in children on antiretroviral therapy.
Van Zyl GU, Katusiime MG, Wiegand A, McManus WR, Bale MJ, Halvas EK, Luke B, Boltz VF, Spindler J, Laughton B, Engelbrecht S, Coffin JM, Cotton MF, Shao W, Mellors JW, Kearney MF. Van Zyl GU, et al. Among authors: wiegand a. J Clin Invest. 2017 Oct 2;127(10):3827-3834. doi: 10.1172/JCI94582. Epub 2017 Sep 11. J Clin Invest. 2017. PMID: 28891813 Free PMC article. Clinical Trial.
HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy.
McManus WR, Bale MJ, Spindler J, Wiegand A, Musick A, Patro SC, Sobolewski MD, Musick VK, Anderson EM, Cyktor JC, Halvas EK, Shao W, Wells D, Wu X, Keele BF, Milush JM, Hoh R, Mellors JW, Hughes SH, Deeks SG, Coffin JM, Kearney MF. McManus WR, et al. Among authors: wiegand a. J Clin Invest. 2019 Jul 30;129(11):4629-4642. doi: 10.1172/JCI126714. J Clin Invest. 2019. PMID: 31361603 Free PMC article. Clinical Trial.
Early Emergence and Long-Term Persistence of HIV-Infected T-Cell Clones in Children.
Bale MJ, Katusiime MG, Wells D, Wu X, Spindler J, Halvas EK, Cyktor JC, Wiegand A, Shao W, Cotton MF, Hughes SH, Mellors JW, Coffin JM, Van Zyl GU, Kearney MF. Bale MJ, et al. Among authors: wiegand a. mBio. 2021 Apr 8;12(2):e00568-21. doi: 10.1128/mBio.00568-21. mBio. 2021. PMID: 33832973 Free PMC article.
Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy.
Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ, Cranmer L, O'Shea A, Callender M, Spivak A, Brennan T, Kearney MF, Proschan MA, Mican JM, Rehm CA, Coffin JM, Mellors JW, Siliciano RF, Maldarelli F. Dinoso JB, et al. Among authors: wiegand am. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9403-8. doi: 10.1073/pnas.0903107106. Epub 2009 May 22. Proc Natl Acad Sci U S A. 2009. PMID: 19470482 Free PMC article.
294 results