Yoon I - Search Results

1

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.

Yoon I, Nam M, Kim HK, Moon HS, Kim S, Jang J, Song JA, Jeong SJ, Kim SB, Cho S, Kim Y, Lee J, Yang WS, Yoo HC, Kim K, Kim MS, Yang A, Cho K, Park HS, Hwang GS, Hwang KY, Han JM, Kim JH, Kim S. Yoon I, et al. Science. 2020 Jan 10;367(6474):205-210. doi: 10.1126/science.aau2753. Epub 2019 Nov 28. Science. 2020. PMID: 31780625

2

AIMP1 negatively regulates adipogenesis by inhibiting PPARγ.

Kim JH, Lee JH, Park MC, Yoon I, Kim K, Lee M, Choi HS, Han JM, Kim S. Kim JH, et al. Among authors: yoon i. J Cell Sci. 2014 Oct 15;127(Pt 20):4483-93. doi: 10.1242/jcs.154930. Epub 2014 Aug 21. J Cell Sci. 2014. PMID: 25146391

3

Discovery of (S)-4-isobutyloxazolidin-2-one as a novel leucyl-tRNA synthetase (LRS)-targeted mTORC1 inhibitor.

Yoon S, Kim JH, Yoon I, Kim C, Kim SE, Koh Y, Jeong SJ, Lee J, Kim S, Lee J. Yoon S, et al. Among authors: yoon i. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3038-3041. doi: 10.1016/j.bmcl.2016.05.011. Epub 2016 May 7. Bioorg Med Chem Lett. 2016. PMID: 27209231

4

Caspase-8 controls the secretion of inflammatory lysyl-tRNA synthetase in exosomes from cancer cells.

Kim SB, Kim HR, Park MC, Cho S, Goughnour PC, Han D, Yoon I, Kim Y, Kang T, Song E, Kim P, Choi H, Mun JY, Song C, Lee S, Jung HS, Kim S. Kim SB, et al. Among authors: yoon i. J Cell Biol. 2017 Jul 3;216(7):2201-2216. doi: 10.1083/jcb.201605118. Epub 2017 Jun 13. J Cell Biol. 2017. PMID: 28611052 Free PMC article.

5

Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

Yoon S, Kim JH, Koh Y, Tran PT, Ann J, Yoon I, Jang J, Kim WK, Lee S, Lee J, Kim S, Lee J. Yoon S, et al. Among authors: yoon i. Bioorg Med Chem. 2017 Aug 1;25(15):4145-4152. doi: 10.1016/j.bmc.2017.06.002. Epub 2017 Jun 2. Bioorg Med Chem. 2017. PMID: 28625715

6

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.

Kim JH, Lee C, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang J, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM, Kim S. Kim JH, et al. Among authors: yoon i. Nat Commun. 2017 Sep 29;8(1):732. doi: 10.1038/s41467-017-00785-0. Nat Commun. 2017. PMID: 28963468 Free PMC article.

7

Inhibition of MUC1 biosynthesis via threonyl-tRNA synthetase suppresses pancreatic cancer cell migration.

Jeong SJ, Kim JH, Lim BJ, Yoon I, Song JA, Moon HS, Kim D, Lee DK, Kim S. Jeong SJ, et al. Among authors: yoon i. Exp Mol Med. 2018 Jan 12;50(1):e424. doi: 10.1038/emm.2017.231. Exp Mol Med. 2018. PMID: 29328069 Free PMC article.

8

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway.

Lee M, Kim JH, Yoon I, Lee C, Fallahi Sichani M, Kang JS, Kang J, Guo M, Lee KY, Han G, Kim S, Han JM. Lee M, et al. Among authors: yoon i. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5279-E5288. doi: 10.1073/pnas.1801287115. Epub 2018 May 21. Proc Natl Acad Sci U S A. 2018. PMID: 29784813 Free PMC article.

9

Discovery of novel leucyladenylate sulfamate surrogates as leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.

Yoon S, Zuo D, Kim JH, Yoon I, Ann J, Kim SE, Cho D, Kim WK, Lee S, Lee J, Kim S, Lee J. Yoon S, et al. Among authors: yoon i. Bioorg Med Chem. 2018 Aug 7;26(14):4073-4079. doi: 10.1016/j.bmc.2018.06.034. Epub 2018 Jun 26. Bioorg Med Chem. 2018. PMID: 30041947

10

Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).

Yoon S, Kim SE, Kim JH, Yoon I, Tran PT, Ann J, Kim C, Byun WS, Lee S, Kim S, Lee J, Lee J. Yoon S, et al. Among authors: yoon i. Bioorg Med Chem. 2019 Mar 15;27(6):1099-1109. doi: 10.1016/j.bmc.2019.01.037. Epub 2019 Jan 30. Bioorg Med Chem. 2019. PMID: 30755350

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