Chen KW - Search Results

1

Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.

Chen KW, Demarco B, Broz P. Chen KW, et al. EMBO J. 2020 Jan 15;39(2):e103397. doi: 10.15252/embj.2019103397. Epub 2019 Dec 3. EMBO J. 2020. PMID: 31793683 Free PMC article. Review.

2

Noncanonical inflammasome signaling elicits gasdermin D-dependent neutrophil extracellular traps.

Chen KW, Monteleone M, Boucher D, Sollberger G, Ramnath D, Condon ND, von Pein JB, Broz P, Sweet MJ, Schroder K. Chen KW, et al. Sci Immunol. 2018 Aug 24;3(26):eaar6676. doi: 10.1126/sciimmunol.aar6676. Sci Immunol. 2018. PMID: 30143554

3

Divide to conquer: NLRP3 is activated on dispersed trans-Golgi network.

Chen KW, Boucher D, Broz P. Chen KW, et al. Cell Res. 2019 Mar;29(3):181-182. doi: 10.1038/s41422-018-0138-z. Cell Res. 2019. PMID: 30664729 Free PMC article. No abstract available.

4

Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly.

Chen KW, Demarco B, Heilig R, Shkarina K, Boettcher A, Farady CJ, Pelczar P, Broz P. Chen KW, et al. EMBO J. 2019 May 15;38(10):e101638. doi: 10.15252/embj.2019101638. Epub 2019 Mar 22. EMBO J. 2019. PMID: 30902848 Free PMC article.

5

Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation.

Demarco B, Chen KW, Broz P. Demarco B, et al. Among authors: chen kw. Mol Cell Oncol. 2019 May 7;6(4):1610324. doi: 10.1080/23723556.2019.1610324. eCollection 2019. Mol Cell Oncol. 2019. PMID: 31211242 Free PMC article.

6

Pannexin-1 promotes NLRP3 activation during apoptosis but is dispensable for canonical or noncanonical inflammasome activation.

Chen KW, Demarco B, Broz P. Chen KW, et al. Eur J Immunol. 2020 Feb;50(2):170-177. doi: 10.1002/eji.201948254. Epub 2019 Aug 29. Eur J Immunol. 2020. PMID: 31411729 Free article.

7

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD.

Heilig R, Dilucca M, Boucher D, Chen KW, Hancz D, Demarco B, Shkarina K, Broz P. Heilig R, et al. Among authors: chen kw. Life Sci Alliance. 2020 Apr 28;3(6):e202000735. doi: 10.26508/lsa.202000735. Print 2020 Jun. Life Sci Alliance. 2020. PMID: 32345661 Free PMC article.

8

Cross talk between intracellular pathogens and cell death.

Demarco B, Chen KW, Broz P. Demarco B, et al. Among authors: chen kw. Immunol Rev. 2020 Sep;297(1):174-193. doi: 10.1111/imr.12892. Epub 2020 Jun 22. Immunol Rev. 2020. PMID: 32567717 Review.

9

Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.

Santos JC, Boucher D, Schneider LK, Demarco B, Dilucca M, Shkarina K, Heilig R, Chen KW, Lim RYH, Broz P. Santos JC, et al. Among authors: chen kw. Nat Commun. 2020 Jun 24;11(1):3276. doi: 10.1038/s41467-020-16889-z. Nat Commun. 2020. PMID: 32581219 Free PMC article.

10

Caspase-8-dependent gasdermin D cleavage promotes antimicrobial defense but confers susceptibility to TNF-induced lethality.

Demarco B, Grayczyk JP, Bjanes E, Le Roy D, Tonnus W, Assenmacher CA, Radaelli E, Fettrelet T, Mack V, Linkermann A, Roger T, Brodsky IE, Chen KW, Broz P. Demarco B, et al. Among authors: chen kw. Sci Adv. 2020 Nov 18;6(47):eabc3465. doi: 10.1126/sciadv.abc3465. Print 2020 Nov. Sci Adv. 2020. PMID: 33208362 Free PMC article.

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