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Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity.
Desiderio A, Longo M, Parrillo L, Campitelli M, Cacace G, de Simone S, Spinelli R, Zatterale F, Cabaro S, Dolce P, Formisano P, Milone M, Miele C, Beguinot F, Raciti GA. Desiderio A, et al. Among authors: spinelli r. Clin Epigenetics. 2019 Dec 4;11(1):181. doi: 10.1186/s13148-019-0768-0. Clin Epigenetics. 2019. PMID: 31801613 Free PMC article.
Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1.
Ungaro P, Mirra P, Oriente F, Nigro C, Ciccarelli M, Vastolo V, Longo M, Perruolo G, Spinelli R, Formisano P, Miele C, Beguinot F. Ungaro P, et al. Among authors: spinelli r. J Biol Chem. 2012 Dec 14;287(51):42951-61. doi: 10.1074/jbc.M112.406637. Epub 2012 Oct 26. J Biol Chem. 2012. PMID: 23105093 Free PMC article.
Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.
Longo M, Spinelli R, D'Esposito V, Zatterale F, Fiory F, Nigro C, Raciti GA, Miele C, Formisano P, Beguinot F, Di Jeso B. Longo M, et al. Among authors: spinelli r. Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1146-56. doi: 10.1016/j.bbamcr.2016.02.019. Epub 2016 Mar 2. Biochim Biophys Acta. 2016. PMID: 26940722 Free article.
Hoxa5 undergoes dynamic DNA methylation and transcriptional repression in the adipose tissue of mice exposed to high-fat diet.
Parrillo L, Costa V, Raciti GA, Longo M, Spinelli R, Esposito R, Nigro C, Vastolo V, Desiderio A, Zatterale F, Ciccodicola A, Formisano P, Miele C, Beguinot F. Parrillo L, et al. Among authors: spinelli r. Int J Obes (Lond). 2016 Jun;40(6):929-37. doi: 10.1038/ijo.2016.36. Epub 2016 Mar 16. Int J Obes (Lond). 2016. PMID: 26980478
Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5.
D'Esposito V, Liguoro D, Ambrosio MR, Collina F, Cantile M, Spinelli R, Raciti GA, Miele C, Valentino R, Campiglia P, De Laurentiis M, Di Bonito M, Botti G, Franco R, Beguinot F, Formisano P. D'Esposito V, et al. Among authors: spinelli r. Oncotarget. 2016 Apr 26;7(17):24495-509. doi: 10.18632/oncotarget.8336. Oncotarget. 2016. PMID: 27027351 Free PMC article.
Epigenetics: spotlight on type 2 diabetes and obesity.
Desiderio A, Spinelli R, Ciccarelli M, Nigro C, Miele C, Beguinot F, Raciti GA. Desiderio A, et al. Among authors: spinelli r. J Endocrinol Invest. 2016 Oct;39(10):1095-103. doi: 10.1007/s40618-016-0473-1. Epub 2016 May 14. J Endocrinol Invest. 2016. PMID: 27180180 Review.
Targetting PED/PEA-15 for diabetes treatment.
Fiory F, Spinelli R, Raciti GA, Parrillo L, D'esposito V, Formisano P, Miele C, Beguinot F. Fiory F, et al. Among authors: spinelli r. Expert Opin Ther Targets. 2017 Jun;21(6):571-581. doi: 10.1080/14728222.2017.1317749. Epub 2017 Apr 21. Expert Opin Ther Targets. 2017. PMID: 28395542 Review.
Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity.
Longo M, Raciti GA, Zatterale F, Parrillo L, Desiderio A, Spinelli R, Hammarstedt A, Hedjazifar S, Hoffmann JM, Nigro C, Mirra P, Fiory F, Formisano P, Miele C, Smith U, Beguinot F. Longo M, et al. Among authors: spinelli r. Diabetologia. 2018 Feb;61(2):369-380. doi: 10.1007/s00125-017-4471-4. Epub 2017 Oct 24. Diabetologia. 2018. PMID: 29067487 Free PMC article.
150 results