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Page 1
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization.
Zhao Z, Kurimchak A, Nikonova AS, Feiser F, Wasserman JS, Fowle H, Varughese T, Connors M, Johnson K, Makhov P, Lindskog C, Kolenko VM, Golemis EA, Duncan JS, Graña X. Zhao Z, et al. Among authors: fowle h. Oncogenesis. 2019 Dec 10;8(12):72. doi: 10.1038/s41389-019-0180-9. Oncogenesis. 2019. PMID: 31822657 Free PMC article.
Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient.
Valentine H, Aiken W, Morrison B, Zhao Z, Fowle H, Wasserman JS, Thompson E, Chin W, Young M, Clarke S, Gibbs D, Harrison S, McLaughlin W, Kwok T, Jin F, Campbell KS, Horvath A, Thompson R, Lee NH, Zhou Y, Graña X, Ragin C, Badal S. Valentine H, et al. Among authors: fowle h. Cancer Res Commun. 2022 Nov;2(11):1355-1371. doi: 10.1158/2767-9764.crc-22-0245. Epub 2022 Nov 7. Cancer Res Commun. 2022. PMID: 36643868 Free PMC article.
FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs.
Wasserman JS, Faezov B, Patel KR, Kurimchak AM, Palacio SM, Glass DJ, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL Jr, Graña X. Wasserman JS, et al. Among authors: fowle h. Nat Commun. 2024 Jul 10;15(1):5776. doi: 10.1038/s41467-024-50015-7. Nat Commun. 2024. PMID: 38982062 Free PMC article.
Derivation of human primary prostate epithelial cell lines by differentially targeting the CDKN2A locus along with expression of hTERT.
Wasserman JS, Fowle H, Hashmi R, Atar D, Patel K, Yarmahmoodi A, Macfarlane AW, Tan Y, Cukierman E, Gligorijevic B, Karami A, Whelan KA, Campbell KS, Graña X. Wasserman JS, et al. Among authors: fowle h. Res Sq [Preprint]. 2024 May 6:rs.3.rs-4294058. doi: 10.21203/rs.3.rs-4294058/v1. Res Sq. 2024. Update in: Sci Rep. 2024 Sep 2;14(1):20409. doi: 10.1038/s41598-024-71306-5 PMID: 38766032 Free PMC article. Updated. Preprint.
FAM122A ensures cell cycle interphase progression and checkpoint control as a SLiM-dependent substrate-competitive inhibitor to the B55⍺/PP2A phosphatase.
Wasserman JS, Faezov B, Patel KR, Kurimchak AN, Palacio SM, Fowle H, McEwan BC, Xu Q, Zhao Z, Cressey L, Johnson N, Duncan JS, Kettenbach AN, Dunbrack RL, Graña X. Wasserman JS, et al. Among authors: fowle h. bioRxiv [Preprint]. 2023 Mar 17:2023.03.06.531310. doi: 10.1101/2023.03.06.531310. bioRxiv. 2023. PMID: 36945596 Free PMC article. Preprint.
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