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LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Tang F, Gao R, Jeevan-Raj B, Wyss CB, Kalathur RKR, Piscuoglio S, Ng CKY, Hindupur SK, Nuciforo S, Dazert E, Bock T, Song S, Buechel D, Morini MF, Hergovich A, Matthias P, Lim DS, Terracciano LM, Heim MH, Hall MN, Christofori G. Tang F, et al. Among authors: hergovich a. Nat Commun. 2019 Dec 17;10(1):5755. doi: 10.1038/s41467-019-13591-7. Nat Commun. 2019. PMID: 31848340 Free PMC article.
NDR functions as a physiological YAP1 kinase in the intestinal epithelium.
Zhang L, Tang F, Terracciano L, Hynx D, Kohler R, Bichet S, Hess D, Cron P, Hemmings BA, Hergovich A, Schmitz-Rohmer D. Zhang L, et al. Among authors: hergovich a. Curr Biol. 2015 Feb 2;25(3):296-305. doi: 10.1016/j.cub.2014.11.054. Epub 2015 Jan 15. Curr Biol. 2015. PMID: 25601544 Free PMC article.
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility.
Tang F, Gill J, Ficht X, Barthlott T, Cornils H, Schmitz-Rohmer D, Hynx D, Zhou D, Zhang L, Xue G, Grzmil M, Yang Z, Hergovich A, Hollaender GA, Stein JV, Hemmings BA, Matthias P. Tang F, et al. Among authors: hergovich a. Sci Signal. 2015 Oct 6;8(397):ra100. doi: 10.1126/scisignal.aab2425. Sci Signal. 2015. PMID: 26443704
MST1/2 Kinase Assays Using Recombinant Proteins.
Gomez M, Kulaberoglu Y, Hergovich A. Gomez M, et al. Among authors: hergovich a. Methods Mol Biol. 2019;1893:319-331. doi: 10.1007/978-1-4939-8910-2_24. Methods Mol Biol. 2019. PMID: 30565144
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2.
Guilhamon P, Eskandarpour M, Halai D, Wilson GA, Feber A, Teschendorff AE, Gomez V, Hergovich A, Tirabosco R, Fernanda Amary M, Baumhoer D, Jundt G, Ross MT, Flanagan AM, Beck S. Guilhamon P, et al. Among authors: hergovich a. Nat Commun. 2013;4:2166. doi: 10.1038/ncomms3166. Nat Commun. 2013. PMID: 23863747 Free PMC article.
73 results