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Novel coumarins active against Trypanosoma cruzi and toxicity assessment using the animal model Caenorhabditis elegans.
Soares FGN, Göethel G, Kagami LP, das Neves GM, Sauer E, Birriel E, Varela J, Gonçalves IL, Von Poser G, González M, Kawano DF, Paula FR, de Melo EB, Garcia SC, Cerecetto H, Eifler-Lima VL. Soares FGN, et al. Among authors: varela j. BMC Pharmacol Toxicol. 2019 Dec 19;20(Suppl 1):76. doi: 10.1186/s40360-019-0357-z. BMC Pharmacol Toxicol. 2019. PMID: 31852548 Free PMC article.
Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity.
Alvarez G, Aguirre-López B, Varela J, Cabrera M, Merlino A, López GV, Lavaggi ML, Porcal W, Di Maio R, González M, Cerecetto H, Cabrera N, Pérez-Montfort R, de Gómez-Puyou MT, Gómez-Puyou A. Alvarez G, et al. Among authors: varela j. Eur J Med Chem. 2010 Dec;45(12):5767-72. doi: 10.1016/j.ejmech.2010.09.034. Epub 2010 Sep 19. Eur J Med Chem. 2010. PMID: 20889239
Activity on Trypanosoma cruzi, erythrocytes lysis and biologically relevant physicochemical properties of Pd(II) and Pt(II) complexes of thiosemicarbazones derived from 1-indanones.
Santos D, Parajón-Costa B, Rossi M, Caruso F, Benítez D, Varela J, Cerecetto H, González M, Gómez N, Caputto ME, Moglioni AG, Moltrasio GY, Finkielsztein LM, Gambino D. Santos D, et al. Among authors: varela j. J Inorg Biochem. 2012 Dec;117:270-6. doi: 10.1016/j.jinorgbio.2012.08.024. Epub 2012 Sep 24. J Inorg Biochem. 2012. PMID: 23063173
Expanding the family of heteroleptic oxidovanadium(IV) compounds with salicylaldehyde semicarbazones and polypyridyl ligands showing anti-Trypanosoma cruzi activity.
Scalese G, Benítez J, Rostán S, Correia I, Bradford L, Vieites M, Minini L, Merlino A, Coitiño EL, Birriel E, Varela J, Cerecetto H, González M, Pessoa JC, Gambino D. Scalese G, et al. Among authors: varela j. J Inorg Biochem. 2015 Jun;147:116-25. doi: 10.1016/j.jinorgbio.2015.03.002. Epub 2015 Mar 12. J Inorg Biochem. 2015. PMID: 25824466
Development of bis-thiazoles as inhibitors of triosephosphate isomerase from Trypanosoma cruzi. Identification of new non-mutagenic agents that are active in vivo.
Álvarez G, Martínez J, Varela J, Birriel E, Cruces E, Gabay M, Leal SM, Escobar P, Aguirre-López B, Cabrera N, Tuena de Gómez-Puyou M, Gómez Puyou A, Pérez-Montfort R, Yaluff G, Torres S, Serna E, Vera de Bilbao N, González M, Cerecetto H. Álvarez G, et al. Among authors: varela j. Eur J Med Chem. 2015 Jul 15;100:246-56. doi: 10.1016/j.ejmech.2015.06.018. Epub 2015 Jun 12. Eur J Med Chem. 2015. PMID: 26094151
1,032 results