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Page 1
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome.
Gross CC, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher AR, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud DA, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG, Martin-Blondel G, Wiendl H, Liblau R. Gross CC, et al. Among authors: herich s. Nat Commun. 2019 Dec 18;10(1):5779. doi: 10.1038/s41467-019-13593-5. Nat Commun. 2019. PMID: 31852955 Free PMC article.
Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.
Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjević M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H. Gross CC, et al. Among authors: herich s. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2973-82. doi: 10.1073/pnas.1524924113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162345 Free PMC article.
Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus.
Breuer J, Korpos E, Hannocks MJ, Schneider-Hohendorf T, Song J, Zondler L, Herich S, Flanagan K, Korn T, Zarbock A, Kuhlmann T, Sorokin L, Wiendl H, Schwab N. Breuer J, et al. Among authors: herich s. J Neuroinflammation. 2018 Aug 22;15(1):236. doi: 10.1186/s12974-018-1276-4. J Neuroinflammation. 2018. PMID: 30134924 Free PMC article.
Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis.
Herich S, Schneider-Hohendorf T, Rohlmann A, Khaleghi Ghadiri M, Schulte-Mecklenbeck A, Zondler L, Janoschka C, Ostkamp P, Richter J, Breuer J, Dimitrov S, Rammensee HG, Grauer OM, Klotz L, Gross CC, Stummer W, Missler M, Zarbock A, Vestweber D, Wiendl H, Schwab N. Herich S, et al. Brain. 2019 Nov 1;142(11):3411-3427. doi: 10.1093/brain/awz301. Brain. 2019. PMID: 31563951
Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis.
Holm Hansen R, Talbot J, Højsgaard Chow H, Bredahl Hansen M, Buhelt S, Herich S, Schwab N, Hellem MNN, Nielsen JE, Sellebjerg F, von Essen MR. Holm Hansen R, et al. Among authors: herich s. Neurol Neuroimmunol Neuroinflamm. 2022 Jul 14;9(5):e200009. doi: 10.1212/NXI.0000000000200009. Print 2022 Sep. Neurol Neuroimmunol Neuroinflamm. 2022. PMID: 35835563 Free PMC article.