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ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP, Tzahor E. D'Uva G, et al. Among authors: tzahor e. Nat Cell Biol. 2015 May;17(5):627-38. doi: 10.1038/ncb3149. Epub 2015 Apr 6. Nat Cell Biol. 2015. PMID: 25848746
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grün D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J. Honkoop H, et al. Among authors: tzahor e. Elife. 2019 Dec 23;8:e50163. doi: 10.7554/eLife.50163. Elife. 2019. PMID: 31868166 Free PMC article.
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.
Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach OY, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E. Aharonov A, et al. Among authors: tzahor e. Nat Cell Biol. 2020 Nov;22(11):1346-1356. doi: 10.1038/s41556-020-00588-4. Epub 2020 Oct 12. Nat Cell Biol. 2020. PMID: 33046882
Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury.
Shakked A, Petrover Z, Aharonov A, Ghiringhelli M, Umansky KB, Kain D, Elkahal J, Divinsky Y, Nguyen PD, Miyara S, Friedlander G, Savidor A, Zhang L, Perez DE, Sarig R, Lendengolts D, Bueno-Levy H, Kastan N, Levin Y, Bakkers J, Gepstein L, Tzahor E. Shakked A, et al. Among authors: tzahor e. Nat Cardiovasc Res. 2023 Apr;2(4):383-398. doi: 10.1038/s44161-023-00250-w. Epub 2023 Mar 8. Nat Cardiovasc Res. 2023. PMID: 37974970 Free PMC article.
69 results